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Journal of Neuroscience, Vol 7, 3544-3553, Copyright © 1987 by Society for Neuroscience
Terminal arbors of axons projecting to the somatosensory cortex of the adult rat. II. The altered morphology of thalamocortical afferents following neonatal infraorbital nerve cut
KF Jensen and HP Killackey
Department of Psychobiology, University of California, Irvine 92717.
The organization of the whisker representation within the neocortex of the
rat is dependent on an intact periphery during development. To further
investigate how alterations in this cortical map arise we examined the
organization of thalamocortical afferents to the whisker representation in
adult animals in which the infraorbital branch of the trigeminal nerve was
cut on the day of birth. The disrupted pattern of thalamocortical
projections to the vibrissae representation was apparent in the abnormal
pattern of the anterograde transport of horseradish peroxidase from the
thalamus, as well as in the abnormal pattern of succinate dehydrogenase
activity. To determine the morphology of individual thalamocortical axons
associated with this disrupted pattern, terminal arbors were "bulk-labeled"
by injections of horseradish peroxidase into the white matter beneath the
somatosensory cortex. Terminal arbors were identified by their laminar
distribution of boutons corresponding to the specific thalamocortical
afferent. The medial to lateral extent of these terminal arbors varied
dramatically, from 350 to 1500 microns. In addition, terminal arbors
innervating the same local area of cortex appeared to have varying degrees
of overlap. Thus, the disruption of the neocortical vibrissae
representation appears to involve the abnormal arborization of individual
thalamocortical afferents. This finding supports the hypothesis that the
fine-grain organization of the somatotopic map is dependent on the
morphology and organization of individual thalamocortical arbors, which, in
turn, are dependent on the periphery during development.
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