 |
 Previous Article | Next Article 
Journal of Neuroscience, Vol 7, 4129-4136, Copyright © 1987 by Society for Neuroscience
Neurogenically mediated leakage of plasma protein occurs from blood vessels in dura mater but not brain
S Markowitz, K Saito and MA Moskowitz
Stroke Research Laboratory, Massachusetts General Hospital, Boston 02114.
Utilizing 125I-BSA administered intravenously, a simple, reliable, and
sensitive method was established for the detection of plasma protein
extravasation in the dura of rats and guinea pigs following chemical,
electrical, or immunological stimulation. Extravasated 125I-BSA or Evans
blue was noted in the dura and conjunctiva but not in the temporalis muscle
of saline-perfused rats following intravenous capsaicin, 1 mumol/kg.
Capsaicin-induced extravasation was mediated by unmyelinated and small
myelinated fibers since leakage did not develop in adult animals in whom
these fibers were destroyed by capsaicin pretreatment (50 mg/kg) as
neonates. An ipsilateral increase in Evans blue and 125I-BSA was found in
the dura, eyelids, lips and gingival mucosa, and snout following electrical
stimulation of the rat trigeminal ganglion. This increase was also C-fiber
dependent. Among those peptides contained in perivascular afferent fibers
and administered intravenously, substance P (SP) and neurokinin A (NKA),
but not calcitonin gene-related peptide, caused a dose-dependent
extravasation in the dura and conjunctiva of rats. Neonatal capsaicin
pretreatment did not attenuate SP- nor NKA-induced effects in the dura and
actually increased extravasation in the conjunctiva. Intravenous
administration of 5-HT or bradykinin to normal adult rats or adult rats
pretreated as neonates with capsaicin increased levels of 125I-BSA in both
the dura and the conjunctiva. Histamine and prostaglandin E2, on the other
hand, caused protein leakage in the conjunctiva but not in the dura of
rats; however, histamine did induce extravasation in the dura of guinea
pigs.(ABSTRACT TRUNCATED AT 250 WORDS)
This article has been cited by other articles:
|
|
|
|
 
A. H. Ahn and A. I. Basbaum
Tissue Injury Regulates Serotonin 1D Receptor Expression: Implications for the Control of Migraine and Inflammatory Pain.
J. Neurosci.,
August 9, 2006;
26(32):
8332 - 8338.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Waeber and M. A. Moskowitz
Migraine as an inflammatory disorder
Neurology,
May 24, 2005;
64(10_suppl_2):
S9 - S15.
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Levy, M. Jakubowski, and R. Burstein
Disruption of communication between peripheral and central trigeminovascular neurons mediates the antimigraine action of 5HT1B/1D receptor agonists
PNAS,
March 23, 2004;
101(12):
4274 - 4279.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
U. Reuter, H. Bolay, I. Jansen-Olesen, A. Chiarugi, M. S. del Rio, R. Letourneau, T. C. Theoharides, C. Waeber, and M. A. Moskowitz
Delayed inflammation in rat meninges: implications for migraine pathophysiology
Brain,
December 1, 2001;
124(12):
2490 - 2502.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. K. Singh, W. Boucher, X. Pang, R. Letourneau, D. Seretakis, M. Green, and T. C. Theoharides
Potent Mast Cell Degranulation and Vascular Permeability Triggered by Urocortin Through Activation of Corticotropin-Releasing Hormone Receptors
J. Pharmacol. Exp. Ther.,
March 1, 1999;
288(3):
1349 - 1356.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
R. L. McLeod, R. Aslanian, M. del Prado, R. Duffy, R. W. Egan, W. Kreutner, R. McQuade, and J. A. Hey
Sch 50971, an Orally Active Histamine H3 Receptor Agonist, Inhibits Central Neurogenic Vascular Inflammation and Produces Sedation in the Guinea Pig
J. Pharmacol. Exp. Ther.,
October 1, 1998;
287(1):
43 - 50.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
T. C. Theoharides, L. K. Singh, W. Boucher, X. Pang, R. Letourneau, E. Webster, and G. Chrousos
Corticotropin-Releasing Hormone Induces Skin Mast Cell Degranulation and Increased Vascular Permeability, A Possible Explanation for Its Proinflammatory Effects
Endocrinology,
January 1, 1998;
139(1):
403 - 413.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. A. Moskowitz and C. Waeber
Migraine Enters the Molecular Era
Neuroscientist,
May 1, 1996;
2(3):
191 - 200.
[Abstract]
[PDF]
|
|
|
|
