QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Redburn, D. A. Articles by Churchill, L. Search for Related Content PubMed PubMed Citation Articles by Redburn, D. A. Articles by Churchill, L.

 Previous Article  |  Next Article 

Journal of Neuroscience, Vol 7, 319-329, Copyright © 1987 by Society for Neuroscience

ARTICLE

An indoleamine system in photoreceptor cell terminals of the Long-Evans rat retina

DA Redburn and L Churchill

Uptake of 3H-serotonin is localized to the outer plexiform layer in Long-Evans rat retinas. Autoradiographic accumulation is seen only after in vitro incubation in the light, with retinas isolated from the underlying sclera. Potassium stimulates the release of 3H-serotonin. In this species, amacrine cells do not accumulate these compounds; thus the outer plexiform layer appears to be the only site of uptake and release of this indoleamine. The age-related loss of 3H-serotonin accumulation in the outer plexiform layer of retinal dystrophic rats coincides temporally with the spontaneous degeneration of photoreceptor cells that occurs in this species. Electron-microscopic autoradiography of 3H-serotonin accumulation further confirms that uptake is localized to rod and cone terminals in the outer plexiform layer. The specific accumulation of indoleamines into rod and cone terminals that is observed in the light but is absent in darkness suggests that indoles have an important physiological role in photoreceptors.

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help