WWW.JNEUROSCI.ORG
-
The Journal of Neuroscience Join the AAN today!
QUICK SEARCH:   [advanced]


     
-


HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP
This Article
Right arrow Full Text (PDF)
Right arrow Submit an eLetter
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hoshi, T.
Right arrow Articles by Smith, S. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hoshi, T.
Right arrow Articles by Smith, S. J.

 Previous Article  |  Next Article 

Journal of Neuroscience, Vol 7, 571-580, Copyright © 1987 by Society for Neuroscience

ARTICLE

Large depolarization induces long openings of voltage-dependent calcium channels in adrenal chromaffin cells

T Hoshi and SJ Smith

Single Ca2+-channel currents in bovine adrenal chromaffin cells were studied with the patch-clamp technique using Ba2+ as the charge carrier. Depolarizing pulses to voltages less than +10 mV from holding voltage of -60 mV elicited short openings with a mean life time of less than 1 msec. Depolarization to more positive voltages elicited longer openings with a mean life time of about 3 msec in addition to the short openings similar to those observed at less positive voltages. Following large depolarizing prepulses, 2 types of "tail" openings, one with a mean duration of less than 1 msec and the other with a mean duration of 4 msec, were observed. In the presence of a dihydropyridine BAY K 8644, openings with a mean duration of more than 12 msec were present. Depolarization-induced long openings and BAY K 8644-produced long openings differed in the first latency and open-time properties. The results could be explained in terms of multiple open states of one type of Ca2+ channel. A kinetic model with at least 2 open states is required to explain activation of Ca2+ channels in chromaffin cells.


This article has been cited by other articles:


Home page
 Biophys. JHome page
A. Giancippoli, M. Novara, A. de Luca, P. Baldelli, A. Marcantoni, E. Carbone, and V. Carabelli
Low-Threshold Exocytosis Induced by cAMP-Recruited CaV3.2 ({alpha}1H) Channels in Rat Chromaffin Cells
Biophys. J., March 1, 2006; 90(5): 1830 - 1841.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. Albillos, E. Neher, and T. Moser
R-Type Ca2+ Channels Are Coupled to the Rapid Component of Secretion in Mouse Adrenal Slice Chromaffin Cells
J. Neurosci., November 15, 2000; 20(22): 8323 - 8330.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. M. Mulvaney, T. Zhang, C. Fewtrell, and M. S. Roberson
Calcium Influx through L-type Channels Is Required for Selective Activation of Extracellular Signal-regulated Kinase by Gonadotropin-releasing Hormone
J. Biol. Chem., October 15, 1999; 274(42): 29796 - 29804.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
E. T. Kavalali, K. S. Hwang, and M. R. Plummer
cAMP-Dependent Enhancement of Dihydropyridine-Sensitive Calcium Channel Availability in Hippocampal Neurons
J. Neurosci., July 15, 1997; 17(14): 5334 - 5348.
[Abstract] [Full Text] [PDF]


-

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help
-
Copyright 2008 by Society for Neuroscience ONLINE ISSN: 1529-2401
-