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Journal of Neuroscience, Vol 7, 671-681, Copyright © 1987 by Society for Neuroscience
Peptidergic modulation of neuronal circuitry controlling feeding in Aplysia
WS Sossin, MD Kirk and RH Scheller
We examined the effects of 3 neuropeptides and the bioactive amine 5-HT on
identified motoneurons (B15 and B16) and interneurons (B4, B5) involved in
the control of feeding behavior in Aplysia californica. The application of
egg-laying hormone (ELH), small cardioactive peptide b (SCPb), and 5-HT
elicits distinct patterns of synaptically induced bursting in the neurons,
while PheMetArgPheamide (FMRFamide) inhibits firing due to synaptic
activity. Repetitive IPSPs recorded in B15 and B16 are induced by 5-HT and
SCPb and inhibited by FMRFamide. The substances also may act directly: In
solutions that block synaptic transmission SCPb excites B15, ELH excites
B16, 5-HT excites B15, B16, and B4, and FMRFamide both inhibits B15 and B16
and excites B4. We suggest that the output of a buccal ganglion central
pattern generator may be modulated to produce distinct patterns of
motoneuron activity by these candidate transmitters. We also noted
differences in the intrinsic properties of the 2 motoneurons. B15 contains
SCPb immunoreactivity while B16 does not. This finding suggests that B15
may be the source for the SCPb immunoreactivity previously found at the ARC
muscle and that SCPb may be acting in an autocrine mode. Also, B15 has a
significantly lower resting potential than B16 and contains a large
transient outward (Ia-like) current. The candidate transmitters act by
exciting or inhibiting elements at every level within the hierarchically
organized motor system that controls feeding. This expands the diversity of
behavioral repertoires that may be elicited from a particular neural
circuit.
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