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Journal of Neuroscience, Vol 7, 774-780, Copyright © 1987 by Society for Neuroscience
Long-term potentiation in the hippocampus using depolarizing current pulses as the conditioning stimulus to single volley synaptic potentials
B Gustafsson, H Wigstrom, WC Abraham and YY Huang
The conditions responsible for the associative properties of long-term
potentiation (LTP) were examined in the CA1 region of the hippocampal slice
preparation. Intracellularly recorded EPSPs resulting from single- volley
stimulation at low frequency (0.15-0.1 Hz) in the stratum radiatum or
oriens were paired with depolarizing current pulses (50-100 msec) injected
through the recording microelectrode. It is shown that these EPSPs, when
paired with pulses of sufficient magnitude, become potentiated. This
potentiation generally reached a peak after 20-30 pairing events and could
outlast the conditioning period by more than 1 hr. It was specific to the
paired input, was blocked by 2-amino-5- phosphonovalerate (APV) and was
largely blocked by prior homosynaptic tetanization (and vice versa). In
experiments performed with picrotoxin (PTX) in the bath, EPSPs were
potentiated using 2-4 nA current pulses, with somewhat higher values in
normal solution. The effective current pulses, in both normal and PTX
solution, produced a repetitive spike discharge of 7-11 spikes (per 100
msec), and within this range, higher frequencies were associated with
larger potentiations. However, since similar degrees of EPSP potentiation
were observed following blockade of spike activity by intracellular QX-314,
spike activity was not the primary conditioning factor. For the
potentiation to appear, the EPSP had to occur together with the current
pulse or precede it by less than about 100 msec. No potentiation was
observed when the EPSP immediately succeeded the pulse. The results suggest
that the cooperativity aspect of LTP is related to a need for sufficient
postsynaptic depolarization.(ABSTRACT TRUNCATED AT 250 WORDS)
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|
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|
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|
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|
|
|
|
|
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|
|
|
|
|
|
|
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|
|
|
|
|
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|
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[Full Text]
[PDF]
|
|
|
|
|
|
|
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[Abstract]
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|
|
|
|
|
|
|
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[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
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February 1, 1999;
81(2):
781 - 787.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
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2108 - 2117.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
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Learn. Mem.,
January 1, 1998;
4(6):
510 - 518.
[Abstract]
[PDF]
|
|
|
|
|
|
|
Y. Wang, J. Wu, M. J. Rowan, and R. Anwyl
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J Neurophysiol,
November 1, 1997;
78(5):
2569 - 2573.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
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PNAS,
September 16, 1997;
94(19):
10403 - 10408.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Shen, C. A. Barnes, B. L. McNaughton, W. E. Skaggs, and K. L. Weaver
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J. Neurosci.,
September 1, 1997;
17(17):
6769 - 6782.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Tsubokawa and W. N. Ross
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J. Neurosci.,
August 1, 1997;
17(15):
5782 - 5791.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
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J Neurophysiol,
March 1, 1997;
77(3):
1269 - 1283.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
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J Neurophysiol,
February 1, 1997;
77(2):
667 - 674.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. C. Magee and D. Johnston
A Synaptically Controlled, Associative Signal for Hebbian Plasticity in Hippocampal Neurons
Science,
January 10, 1997;
275(5297):
209 - 213.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
H. Markram, J. Lübke, M. Frotscher, and B. Sakmann
Regulation of Synaptic Efficacy by Coincidence of Postsynaptic APs and EPSPs
Science,
January 10, 1997;
275(5297):
213 - 215.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
N. A. Otmakhova and J. E. Lisman
D1/D5 Dopamine Receptor Activation Increases the Magnitude of Early Long-Term Potentiation at CA1 Hippocampal Synapses
J. Neurosci.,
December 1, 1996;
16(23):
7478 - 7486.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Reyes and P. K. Stanton
Induction of Hippocampal Long-Term Depression Requires Release of Ca2+ from Separate Presynaptic and Postsynaptic Intracellular Stores
J. Neurosci.,
October 1, 1996;
16(19):
5951 - 5960.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Maccaferri and C. J. McBain
Long-Term Potentiation in Distinct Subtypes of Hippocampal Nonpyramidal Neurons
J. Neurosci.,
September 1, 1996;
16(17):
5334 - 5343.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
X Xie, G Barrionuevo, and T W Berger
Differential expression of short-term potentiation by AMPA and NMDA receptors in dentate gyrus.
Learn. Mem.,
January 1, 1996;
3(2-3):
115 - 123.
[Abstract]
[PDF]
|
|
|
|
|
|
|
C A Barnes, G Rao, and B L McNaughton
Functional integrity of NMDA-dependent LTP induction mechanisms across the lifespan of F-344 rats.
Learn. Mem.,
January 1, 1996;
3(2-3):
124 - 137.
[Abstract]
[PDF]
|
|
|
|
|
|
|
D Liao and R Malinow
Deficiency in induction but not expression of LTP in hippocampal slices from young rats.
Learn. Mem.,
January 1, 1996;
3(2-3):
138 - 149.
[Abstract]
[PDF]
|
|
|
|
|
|
|
O Jensen, M A Idiart, and J E Lisman
Physiologically realistic formation of autoassociative memory in networks with theta/gamma oscillations: role of fast NMDA channels.
Learn. Mem.,
January 1, 1996;
3(2-3):
243 - 256.
[Abstract]
[PDF]
|
|
|
|
|
|
|
O Jensen and J E Lisman
Theta/gamma networks with slow NMDA channels learn sequences and encode episodic memory: role of NMDA channels in recall.
Learn. Mem.,
January 1, 1996;
3(2-3):
264 - 278.
[Abstract]
[PDF]
|
|
|
|
|
|
|
N Spruston, Y Schiller, G Stuart, and B Sakmann
Activity-dependent action potential invasion and calcium influx into hippocampal CA1 dendrites
Science,
April 14, 1995;
268(5208):
297 - 300.
[Abstract]
[PDF]
|
|
|
|
|
|
|
R. C. Malenka
REVIEW {blacksquare} : LTP and LTD: Dynamic and Interactive Processes of Synaptic Plasticity
Neuroscientist,
January 1, 1995;
1(1):
35 - 42.
[Abstract]
[PDF]
|
|
|
|
