 |
 Previous Article | Next Article 
Journal of Neuroscience, Vol 7, 1215-1222, Copyright © 1987 by Society for Neuroscience
Visualization of neuromuscular junctions over periods of several months in living mice
JW Lichtman, L Magrassi and D Purves
Identified neuromuscular junctions were followed in the sternomastoid
muscle of living mice for several months by repeated staining with the
fluorescent dye 4-(4-diethylaminostyryl)-N-methylpyridinium iodide (4-
Di-2-ASP; Magrassi et al., 1987). Overall terminal growth occurred at many
endplates; however, the branching pattern of presynaptic arbors was largely
unchanged, even after several months. The absence of significant remodeling
over time was not a result of dye-staining, since sprouting was readily
induced at residual motor endings by partial denervation. We conclude
that--apart from overall growth--most neuromuscular junctions in the adult
mouse are stable over intervals that represent a significant fraction of
the animal's lifetime.
This article has been cited by other articles:
|
|
|
|
 
I. Martinez-Pena y Valenzuela and M. Akaaboune
Acetylcholinesterase Mobility and Stability at the Neuromuscular Junction of Living Mice
Mol. Biol. Cell,
August 1, 2007;
18(8):
2904 - 2911.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Kang, L. Tian, Y.-J. Son, Y. Zuo, D. Procaccino, F. Love, C. Hayworth, J. Trachtenberg, M. Mikesh, L. Sutton, et al.
Regulation of the Intermediate Filament Protein Nestin at Rodent Neuromuscular Junctions by Innervation and Activity
J. Neurosci.,
May 30, 2007;
27(22):
5948 - 5957.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. M. McCann, Q. T. Nguyen, H. Santo Neto, and J. W. Lichtman
Rapid Synapse Elimination after Postsynaptic Protein Synthesis Inhibition In Vivo
J. Neurosci.,
May 30, 2007;
27(22):
6064 - 6067.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. G. Bruneau and M. Akaaboune
The dynamics of recycled acetylcholine receptors at the neuromuscular junction in vivo
Development,
November 15, 2006;
133(22):
4485 - 4493.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. C. Bruusgaard, K. Liestol, and K. Gundersen
Distribution of myonuclei and microtubules in live muscle fibers of young, middle-aged, and old mice
J Appl Physiol,
June 1, 2006;
100(6):
2024 - 2030.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Krejci, I. M.-P. y Valenzuela, R. Ameziane, and M. Akaaboune
Acetylcholinesterase Dynamics at the Neuromuscular Junction of Live Animals
J. Biol. Chem.,
April 14, 2006;
281(15):
10347 - 10354.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Bruneau, D. Sutter, R. I. Hume, and M. Akaaboune
Identification of Nicotinic Acetylcholine Receptor Recycling and Its Role in Maintaining Receptor Density at the Neuromuscular Junction In Vivo
J. Neurosci.,
October 26, 2005;
25(43):
9949 - 9959.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Z. Feng, S. Koirala, and C.-P. Ko
Synapse-Glia Interactions at the Vertebrate Neuromuscular Junction
Neuroscientist,
October 1, 2005;
11(5):
503 - 513.
[Abstract]
[PDF]
|
|
|
|
|
|
|
I. M.-P. y Valenzuela, R. I. Hume, E. Krejci, and M. Akaaboune
In Vivo Regulation of Acetylcholinesterase Insertion at the Neuromuscular Junction
J. Biol. Chem.,
September 9, 2005;
280(36):
31801 - 31808.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Z. A Rana, K. Gundersen, A. Buonanno, and D. Vullhorst
Imaging transcription in vivo: distinct regulatory effects of fast and slow activity patterns on promoter elements from vertebrate troponin I isoform genes
J. Physiol.,
February 1, 2005;
562(3):
815 - 828.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Zuo, J. L. Lubischer, H. Kang, L. Tian, M. Mikesh, A. Marks, V. L. Scofield, S. Maika, C. Newman, P. Krieg, et al.
Fluorescent Proteins Expressed in Mouse Transgenic Lines Mark Subsets of Glia, Neurons, Macrophages, and Dendritic Cells for Vital Examination
J. Neurosci.,
December 8, 2004;
24(49):
10999 - 11009.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. T. Macleod, P. A. Dickens, and M. R. Bennett
Formation and Function of Synapses with Respect to Schwann Cells at the End of Motor Nerve Terminal Branches on Mature Amphibian (Bufo marinus) Muscle
J. Neurosci.,
April 1, 2001;
21(7):
2380 - 2392.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Blanco, G. R. Coulton, A. Biggin, C. Grainge, J. Moss, M. Barrett, A. Berquin, G. Marechal, M. Skynner, P. van Mier, et al.
The kyphoscoliosis (ky) mouse is deficient in hypertrophic responses and is caused by a mutation in a novel muscle-specific protein
Hum. Mol. Genet.,
January 1, 2001;
10(1):
9 - 16.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Q. T. Nguyen, Y.-J. Son, J. R. Sanes, and J. W. Lichtman
Nerve Terminals Form But Fail to Mature When Postsynaptic Differentiation Is Blocked: In Vivo Analysis Using Mammalian Nerve-Muscle Chimeras
J. Neurosci.,
August 15, 2000;
20(16):
6077 - 6086.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. T. Kavalali, J. Klingauf, and R. W. Tsien
Activity-dependent regulation of synaptic clustering in a hippocampal culture system
PNAS,
October 26, 1999;
96(22):
12893 - 12900.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. de Paiva, F. A. Meunier, J. Molgo, K. R. Aoki, and J. O. Dolly
Functional repair of motor endplates after botulinum neurotoxin type A poisoning: Biphasic switch of synaptic activity between nerve sprouts and their parent terminals
PNAS,
March 16, 1999;
96(6):
3200 - 3205.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. M. Culican, C. C. Nelson, and J. W. Lichtman
Axon Withdrawal during Synapse Elimination at the Neuromuscular Junction Is Accompanied by Disassembly of the Postsynaptic Specialization and Withdrawal of Schwann Cell Processes
J. Neurosci.,
July 1, 1998;
18(13):
4953 - 4965.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. T. Trachtenberg and W. J. Thompson
Nerve Terminal Withdrawal from Rat Neuromuscular Junctions Induced by Neuregulin and Schwann Cells
J. Neurosci.,
August 15, 1997;
17(16):
6243 - 6255.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. A. Fahim
Endurance exercise modulates neuromuscular junction of C57BL/6NNia aging mice
J Appl Physiol,
July 1, 1997;
83(1):
59 - 66.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Wang and E. R. Macagno
The Establishment of Peripheral Sensory Arbors in the Leech: In Vivo Time-Lapse Studies Reveal a Highly Dynamic Process
J. Neurosci.,
April 1, 1997;
17(7):
2408 - 2419.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. H. Astrow, V. Pitaevski, and A. A. Herrera
Precision of Reinnervation and Synaptic Remodeling Observed in Neuromuscular Junctions of Living Frogs
J. Neurosci.,
August 15, 1996;
16(16):
5130 - 5140.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. D. Kocsis
Competition in the Synaptic Marketplace: Activity Is Important
Neuroscientist,
July 1, 1995;
1(4):
185 - 187.
[Abstract]
[PDF]
|
|
|
|
|
|
|
V Parpura, P. Haydon, and E Henderson
Three-dimensional imaging of living neurons and glia with the atomic force microscope
J. Cell Sci.,
January 2, 1993;
104(2):
427 - 432.
[Abstract]
[PDF]
|
|
|
|
|
|
|
D Purves, J. Voyvodic, L Magrassi, and H Yawo
Nerve terminal remodeling visualized in living mice by repeated examination of the same neuron
Science,
November 20, 1987;
238(4830):
1122 - 1126.
[Abstract]
[PDF]
|
|
|
|
