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Journal of Neuroscience, Vol 7, 1780-1791, Copyright © 1987 by Society for Neuroscience
Origin of orientation-selective EPSPs in simple cells of cat visual cortex
D Ferster
According to current theory, orientation selectivity in cortical simple
cells is critically dependent on intracortical synaptic inhibition. In
particular, it is thought that IPSPs evoked by stimuli of the nonpreferred
orientation are required to prevent a neuron from responding to a broadly
tuned excitatory input at any but the preferred orientation. Yet EPSPs
recorded in simple cells are in themselves highly orientation-selective.
How is this possible, when excitation arises primarily from relay cells of
the lateral geniculate nucleus (LGN), which are largely insensitive to
orientation? In this paper, the properties of EPSPs are compared with the
predictions of a model of geniculate excitation of simple cells. The model,
which is derived from the suggestions of Hubel and Wiesel (1962), relies on
the now familiar arrangement of the receptive fields of presynaptic
geniculate cells into lines parallel to the axis of orientation of the
postsynaptic cell. Several properties of the EPSPs observed in simple
cells, and the orientation tuning of simple cells observed in extracellular
experiments, can be accounted for without resorting to intracortical
inhibition.
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