WWW.JNEUROSCI.ORG
-
The Journal of Neuroscience behavioral testing systems
 QUICK SEARCH:   [advanced]


     
-


HOME
  |  
SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article
Right arrow Full Text (PDF)
Right arrow Submit an eLetter
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lewis, D. A.
Right arrow Articles by Morrison, J. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lewis, D. A.
Right arrow Articles by Morrison, J. H.

 Previous Article  |  Next Article 

Journal of Neuroscience, Vol 7, 1799-1808, Copyright © 1987 by Society for Neuroscience


ARTICLE

Laminar and regional distributions of neurofibrillary tangles and neuritic plaques in Alzheimer's disease: a quantitative study of visual and auditory cortices

DA Lewis, MJ Campbell, RD Terry and JH Morrison

The number of Thioflavine S-positive neurofibrillary tangles (NFT) and neuritic plaques (NP) was determined in visual and auditory cortical regions of 8 patients with Alzheimer's disease. On both a regional and laminar basis, NFT exhibited very distinctive and consistent distribution patterns. The mean (+/- SEM) number of NFT in a 250-micron- wide cortical traverse was very low in area 17, primary visual cortex (0.9 +/- 1.0), increased 20-fold in the immediately adjacent visual association cortex of area 18 (19.7 +/- 3.6), and showed a further doubling in area 20, the higher-order visual association cortex of the inferior temporal gyrus (35.5 +/- 8.8). Similar differences in NFT number were present between primary auditory (1.6 +/- 0.5) and auditory association (18.9 +/- 5.4) regions. On a laminar basis, NFT were predominantly present in layers III and V, although there were striking regional differences in the proportion of NFT in these 2 layers. Layer III contained 79% of the NFT in layers III and V in area 18, 41% in area 20, and only 27% in area 22. In contrast, NP showed different, and less specific, regional and laminar distribution patterns. Total NP number was similar in the 3 visual areas, although there were marked regional differences in the type of NP present. Nearly 80% of the NP in area 17 was of the NPc type (i.e., contained a dense, brightly fluorescent core), whereas over 70% of the NP in both areas 18 and 21 was of the NPnc type (i.e., lacked a dense, brightly fluorescent core). NP were present in every cortical layer but were most numerous in layers III and IV. The distinctive distribution patterns of NFT are very similar to the regional and laminar locations of long corticocortical projection neurons in homologous regions of monkey neocortex. This association suggests that NFT reside in the cell bodies of a subpopulation of pyramidal neurons, namely, those that furnish long corticocortical projections. In contrast, the distribution patterns of NP suggest that multiple neuronal systems contribute to their formation.


This article has been cited by other articles:


Home page
Am. J. Neuroradiol.Home page
J. Huang, R.P. Friedland, and A.P. Auchus
Diffusion Tensor Imaging of Normal-Appearing White Matter in Mild Cognitive Impairment and Early Alzheimer Disease: Preliminary Evidence of Axonal Degeneration in the Temporal Lobe
AJNR Am. J. Neuroradiol., November 1, 2007; 28(10): 1943 - 1948.
[Abstract] [Full Text] [PDF]


Home page
BrainHome page
S. J. Teipel, A. L. W. Bokde, C. Born, T. Meindl, M. Reiser, H.-J. Moller, and H. Hampel
Morphological substrate of face matching in healthy ageing and mild cognitive impairment: a combined MRI-fMRI study
Brain, July 1, 2007; 130(7): 1745 - 1758.
[Abstract] [Full Text] [PDF]


Home page
IOVSHome page
F. Berisha, G. T. Feke, C. L. Trempe, J. W. McMeel, and C. L. Schepens
Retinal Abnormalities in Early Alzheimer's Disease
Invest. Ophthalmol. Vis. Sci., May 1, 2007; 48(5): 2285 - 2289.
[Abstract] [Full Text] [PDF]


Home page
BrainHome page
A.-T. Du, N. Schuff, J. H. Kramer, H. J. Rosen, M. L. Gorno-Tempini, K. Rankin, B. L. Miller, and M. W. Weiner
Different regional patterns of cortical thinning in Alzheimer's disease and frontotemporal dementia
Brain, April 1, 2007; 130(4): 1159 - 1166.
[Abstract] [Full Text] [PDF]


Home page
BrainHome page
E. J. Golob, R. Irimajiri, and A. Starr
Auditory cortical activity in amnestic mild cognitive impairment: relationship to subtype and conversion to dementia
Brain, March 1, 2007; 130(3): 740 - 752.
[Abstract] [Full Text] [PDF]


Home page
J Geriatr Psychiatry NeurolHome page
R. D. Terry
Alzheimer's Disease and the Aging Brain
J Geriatr Psychiatry Neurol, September 1, 2006; 19(3): 125 - 128.
[Abstract] [PDF]


Home page
Am. J. Pathol.Home page
T. L. Spires, J. D. Orne, K. SantaCruz, R. Pitstick, G. A. Carlson, K. H. Ashe, and B. T. Hyman
Region-specific Dissociation of Neuronal Loss and Neurofibrillary Pathology in a Mouse Model of Tauopathy
Am. J. Pathol., May 1, 2006; 168(5): 1598 - 1607.
[Abstract] [Full Text] [PDF]


Home page
Am. J. PsychiatryHome page
P. J. Modrego, N. Fayed, and M. A. Pina
Conversion From Mild Cognitive Impairment to Probable Alzheimer's Disease Predicted by Brain Magnetic Resonance Spectroscopy
Am J Psychiatry, April 1, 2005; 162(4): 667 - 675.
[Abstract] [Full Text] [PDF]


Home page
BrainHome page
A. Golby, G. Silverberg, E. Race, S. Gabrieli, J. O'Shea, K. Knierim, G. Stebbins, and J. Gabrieli
Memory encoding in Alzheimer's disease: an fMRI study of explicit and implicit memory
Brain, April 1, 2005; 128(4): 773 - 787.
[Abstract] [Full Text] [PDF]


Home page
Arch NeurolHome page
M. D. Ikonomovic, E. J. Mufson, J. Wuu, D. A. Bennett, and S. T. DeKosky
Reduction of Choline Acetyltransferase Activity in Primary Visual Cortex in Mild to Moderate Alzheimer's Disease
Arch Neurol, March 1, 2005; 62(3): 425 - 430.
[Abstract] [Full Text] [PDF]


Home page
BrainHome page
U. P. Mosimann, J. Felblinger, P. Ballinari, C. W. Hess, and R. M. Muri
Visual exploration behaviour during clock reading in Alzheimer's disease
Brain, February 1, 2004; 127(2): 431 - 438.
[Abstract] [Full Text] [PDF]


Home page
NeurologyHome page
P. Giannakopoulos, F. R. Herrmann, T. Bussiere, C. Bouras, E. Kovari, D. P. Perl, J. H. Morrison, G. Gold, and P. R. Hof
Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer's disease
Neurology, May 13, 2003; 60(9): 1495 - 1500.
[Abstract] [Full Text] [PDF]


Home page
J. Neurol. Neurosurg. PsychiatryHome page
M Bozzali, A Falini, M Franceschi, M Cercignani, M Zuffi, G Scotti, G Comi, and M Filippi
White matter damage in Alzheimer's disease assessed in vivo using diffusion tensor magnetic resonance imaging
J. Neurol. Neurosurg. Psychiatry, June 1, 2002; 72(6): 742 - 746.
[Abstract] [Full Text] [PDF]


Home page
NeurologyHome page
A. Cronin-Golomb, M. Cronin-Golomb, T. E. Dunne, A. C. Brown, K. Jain, P. B. Cipolloni, and S. H. Auerbach
Facial frequency manipulation normalizes face discrimination in AD
Neurology, June 27, 2000; 54(12): 2316 - 2318.
[Abstract] [Full Text] [PDF]


Home page
Arch Gen PsychiatryHome page
L. A. Glantz and D. A. Lewis
Decreased Dendritic Spine Density on Prefrontal Cortical Pyramidal Neurons in Schizophrenia
Arch Gen Psychiatry, January 1, 2000; 57(1): 65 - 73.
[Abstract] [Full Text] [PDF]


Home page
NeurologyHome page
T. Gomez-Isla, W. B. Growdon, M. McNamara, K. Newell, E. Gomez-Tortosa, E. T. Hedley-Whyte, and B. T. Hyman
Clinicopathologic correlates in temporal cortex in dementia with Lewy bodies
Neurology, December 1, 1999; 53(9): 2003 - 2003.
[Abstract] [Full Text]


Home page
Arch NeurolHome page
S. J. Teipel, H. Hampel, P. Pietrini, G. E. Alexander, B. Horwitz, E. Daley, H.-J. Moller, M. B. Schapiro, and S. I. Rapoport
Region-Specific Corpus Callosum Atrophy Correlates With the Regional Pattern of Cortical Glucose Metabolism in Alzheimer Disease
Arch Neurol, April 1, 1999; 56(4): 467 - 473.
[Abstract] [Full Text] [PDF]


Home page
J. Neurol. Neurosurg. PsychiatryHome page
P. T Francis, A. M Palmer, M. Snape, and G. K Wilcock
The cholinergic hypothesis of Alzheimer's disease: a review of progress
J. Neurol. Neurosurg. Psychiatry, February 1, 1999; 66(2): 137 - 147.
[Abstract] [Full Text]


Home page
Proc. Natl. Acad. Sci. USAHome page
Y. Lakmache, M. Lassonde, S. Gauthier, J.-Y. Frigon, and F. Lepore
Interhemispheric disconnection syndrome in Alzheimer's disease
PNAS, July 21, 1998; 95(15): 9042 - 9046.
[Abstract] [Full Text] [PDF]


Home page
Am. J. PsychiatryHome page
M. J. Mentis, G. E. Alexander, J. Krasuski, P. Pietrini, M. L. Furey, M. B. Schapiro, and S. I. Rapoport
Increasing Required Neural Response to Expose Abnormal Brain Function in Mild Versus Moderate or Severe Alzheimer's Disease: PET Study Using Parametric Visual Stimulation
Am J Psychiatry, June 1, 1998; 155(6): 785 - 794.
[Abstract] [Full Text]


Home page
Arch NeurolHome page
H. Hampel, S. J. Teipel, G. E. Alexander, B. Horwitz, D. Teichberg, M. B. Schapiro, and S. I. Rapoport
Corpus Callosum Atrophy Is a Possible Indicator of Region- and Cell Type-Specific Neuronal Degeneration in Alzheimer Disease: A Magnetic Resonance Imaging Analysis
Arch Neurol, February 1, 1998; 55(2): 193 - 198.
[Abstract] [Full Text] [PDF]


Home page
ScienceHome page
J. H. Morrison and P. R. Hof
Life and Death of Neurons in the Aging Brain
Science, October 17, 1997; 278(5337): 412 - 419.
[Abstract] [Full Text]


Home page
Proc. Natl. Acad. Sci. USAHome page
J. D. E. Gabrieli
Memory systems analyses of mnemonic disorders in aging and age-related diseases
PNAS, November 26, 1996; 93(24): 13534 - 13540.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
M. S. Albert
Cognitive and neurobiologic markers of early Alzheimer disease
PNAS, November 26, 1996; 93(24): 13547 - 13551.
[Abstract] [Full Text] [PDF]


Home page
J Geriatr Psychiatry NeurolHome page
R. E. Majocha and C. A. Marotta
Molecular and Genetic Investigations on Alzheimer Brain Amyloid
J Geriatr Psychiatry Neurol, April 1, 1988; 1(2): 65 - 70.
[Abstract] [PDF]



-

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help

-
Copyright 2008 by Society for Neuroscience ONLINE ISSN: 1529-2401
-