QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Fishell, G. Articles by van der Kooy, D. Search for Related Content PubMed PubMed Citation Articles by Fishell, G. Articles by van der Kooy, D.

 Previous Article  |  Next Article 

Journal of Neuroscience, Vol 7, 1969-1978, Copyright © 1987 by Society for Neuroscience

ARTICLE

Pattern formation in the striatum: developmental changes in the distribution of striatonigral neurons

G Fishell and D van der Kooy

The striatum of the mammalian forebrain can be divided into 2 compartments, the patches and the matrix. We have investigated embryonic events involved in the formation of these compartments in rats. Early in development, dopamine fibers from the substantia nigra selectively innervate the patches. In the perinatal striatum, we observed a close match between the distributions of striatal cell bodies with axonal projections to the substantia nigra and patches of afferent dopamine fibers. Striatal cells projecting to the nigra are first seen in the ventrolateral striatum at embryonic day (E) 17. Striatonigral cell bodies are distributed homogeneously through the striatum from E18 to 19. At E20 and until postnatal day 4, these cell bodies are organized into discrete patches. After this time, striatonigral cell bodies assume the dense and homogeneous distribution characteristic of the adult striatum. A retrograde tracer injection in the nigra at E18 (during the early period of homogeneous striatonigral distribution) produces a patchy striatonigral distribution if the embryo is not sacrificed until E21. The number of retrogradely labeled striatonigral cell bodies in a midstriatal section, at times immediately before and after the early homogeneous to patchy changeover did not differ significantly. We suggest that the neurons of the patch compartment of the striatum are born first and project to the substantia nigra first. The patch neurons only become restricted to "patchy" areas as the later-born matrix neurons migrate out into the striatum.

This article has been cited by other articles:

				M. Miura, S. Saino-Saito, M. Masuda, K. Kobayashi, and T. Aosaki Compartment-Specific Modulation of GABAergic Synaptic Transmission by {micro}-Opioid Receptor in the Mouse Striatum with Green Fluorescent Protein-Expressing Dopamine Islands J. Neurosci., September 5, 2007; 27(36): 9721 - 9728. [Abstract] [Full Text] [PDF]

				L. S. Janis, R. M. Cassidy, and L. F. Kromer Ephrin-A Binding and EphA Receptor Expression Delineate the Matrix Compartment of the Striatum J. Neurosci., June 15, 1999; 19(12): 4962 - 4971. [Abstract] [Full Text] [PDF]

				P. G. Bhide, M. Day, E. Sapp, C. Schwarz, A. Sheth, J. Kim, A. B. Young, J. Penney, J. Golden, N. Aronin, et al. Expression of Normal and Mutant Huntingtin in the Developing Brain J. Neurosci., September 1, 1996; 16(17): 5523 - 5535. [Abstract] [Full Text] [PDF]

				G Fishell Striatal precursors adopt cortical identities in response to local cues Development, January 3, 1995; 121(3): 803 - 812. [Abstract] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help