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Journal of Neuroscience, Vol 7, 2129-2134, Copyright © 1987 by Society for Neuroscience
Depletion of dopamine in the caudate nucleus but not in nucleus accumbens impairs reaction-time performance in rats
M Amalric and GF Koob
Impairment of the dopaminergic system in the brain induced by dopamine-
receptor antagonists or by specific neurotoxin terminal lesions results in
motor disturbances in rats. In order to specify further the role of the
different dopamine pathways in the brain on motor function, the performance
of rats trained in an operant reaction-time task was examined after
systemic administration of a dopamine-receptor antagonist,
alpha-flupenthixol, and after specific destruction of dopamine neurons by
6-hydroxydopamine perfusion into the nucleus accumbens or caudate nucleus.
Rats were trained to press a lever and release it as quickly as possible
after a light-cue conditioned stimulus (CS). Reaction time was measured
from the CS to the release of the lever for each trial. alpha-Flupenthixol
(0.2 and 0.4 mg/kg) injected intraperitoneally impaired the reaction-time
performance of the rats. While disruption of dopamine activity in the
nucleus accumbens did not affect the performance of the rats, lesions of
the dopamine terminals of the nigrostriatal pathway in the corpus striatum
(59% decrease in posterior striatal dopamine) significantly impaired
reaction-time performance. These results show that moderate decreases in
dopamine function restricted to the corpus striatum can disrupt sensitive
motor performance, and support the hypothesis that dopamine in the corpus
striatum has a role in the initiation of complex goal- directed responses.
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