WWW.JNEUROSCI.ORG
-
The Journal of Neuroscience Synaptic Systems Antibody Company
QUICK SEARCH:   [advanced]


     
-


HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP
This Article
Right arrow Full Text (PDF)
Right arrow Submit an eLetter
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sewell, W. F.
Right arrow Articles by Mroz, E. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sewell, W. F.
Right arrow Articles by Mroz, E. A.

 Previous Article  |  Next Article 

Journal of Neuroscience, Vol 7, 2465-2475, Copyright © 1987 by Society for Neuroscience

ARTICLE

Neuroactive substances in inner ear extracts

WF Sewell and EA Mroz

To identify the neurotransmitter released by sensory hair cells, as well as to find other substances that might influence neural function of the inner ear, we have prepared extracts from inner ears of fishes (which have large numbers of hair cells), fractionated the extracts, and studied the effects of the fractionated extracts on the discharge rate of afferent fibers innervating hair cells in the lateral line organ of the African clawed frog Xenopus laevis. The extracts contain active substances that do not bind to a cation-exchange resin at neutral pH. Gel-permeation chromatography suggests that at least 2 unidentified excitatory substances are present in the extracts: one of low molecular weight (Mr about 200) and one of high molecular weight (Mr less than or equal to 5000). Some extracts also contain a high- molecular-weight inhibitory substance (Mr greater than 5000). The low- molecular-weight active substance is detected in extracts of inner ear, but not in brain or muscle. The high-molecular-weight excitatory substance is present both in brain and in inner ear.


This article has been cited by other articles:


Home page
 J. Neurophysiol.Home page
R. Dawkins and W. F. Sewell
Afferent Synaptic Transmission in a Hair Cell Organ: Pharmacological and Physiological Analysis of the Role of the Extended Refractory Period
J Neurophysiol, August 1, 2004; 92(2): 1105 - 1115.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
G. P. Bailey and W. F. Sewell
Calcitonin Gene-Related Peptide Suppresses Hair Cell Responses to Mechanical Stimulation in the Xenopus Lateral Line Organ
J. Neurosci., July 1, 2000; 20(13): 5163 - 5169.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
S. Safieddine and R. J. Wenthold
The Glutamate Receptor Subunit delta 1 Is Highly Expressed in Hair Cells of the Auditory and Vestibular Systems
J. Neurosci., October 1, 1997; 17(19): 7523 - 7531.
[Abstract] [Full Text] [PDF]


-

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help
-
Copyright 2008 by Society for Neuroscience ONLINE ISSN: 1529-2401
-