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Journal of Neuroscience, Vol 7, 2529-2536, Copyright © 1987 by Society for Neuroscience
Regional sex differences in progestin receptor induction in the rat hypothalamus: effects of various doses of estradiol benzoate
TJ Brown, AS Clark and NJ MacLusky
In the rat, sex differences in behavioral responsiveness to progesterone
have been correlated with a sex difference in estrogen- induced progestin
receptor induction in the ventromedial nucleus (VMN). It has recently been
suggested that this sex difference in progestin receptor induction may only
be present after treatment with large doses of estrogen. We have evaluated
the sex difference in hypothalamic cytosol progestin receptor induction in
gonadectomized/adrenalectomized rats treated with moderate doses of
estradiol benzoate (EB; 20 micrograms/kg body weight). No sex differences
were detected in cytosol progestin binding in mediobasal hypothalamus or
preoptic area of animals treated with this dose 48 hr before they were
killed. However, a higher level of progestin binding in the VMN of females
than of males was found when these brain regions were examined using a
microdissection technique. Saturation binding analysis of progestin binding
in the VMN indicated that this sex difference in binding reflects a
difference in the number of progestin binding sites, and not a difference
in binding affinity. A dose-response study of progestin receptor induction
in the medial preoptic nucleus (mPON), arcuate- median eminence region
(ARC-ME), and VMN of male and female rats indicated a sex difference in
cytosol progestin binding in the VMN at all EB doses tested (2, 8, 40, or
200 micrograms/kg body weight). No sex differences in cytosol progestin
binding in the mPON or ARC-ME were observed at any of the tested doses.
These results support the idea that the differences in behavioral
sensitivity to progesterone may result in part from sex differences in the
estrogen induction of progestin receptors in the VMN.
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