 |
 Previous Article | Next Article 
Journal of Neuroscience, Vol 8, 4340-4348, Copyright © 1988 by Society for Neuroscience
Comparison of effects of D-1 and D-2 dopamine receptor agonists on neurons in the rat caudate putamen: an electrophysiological study
XT Hu and RY Wang
Department of Psychiatry and Behavioral Sciences, State University of New York, Stony Brook 11794.
Extracellular single-unit recording and microiontophoretic techniques were
used to characterize the pharmacological properties of dopamine (DA)
receptor subtypes within the rat caudate putamen (CPu), a striatal
structure that receives a dense innervation from DA neurons originating
from the substantia nigra pars compacta (A9 DA neurons). Similar to the
action of DA, the DA D-1 receptor agonist (+)SKF-38393 generally
potentiated the activation produced by glutamate (GLU) at low ejection
currents (less than or equal to 5 nA); at higher ejection currents, it
depressed 97% of the CPu neurons tested. By contrast, the D-2 receptor
agonist LY-171555 (quinpirole) was much less effective in affecting the
firing rate of CPu cells. The selective D-1 antagonist SCH-23390,
administered either intravenously or iontophoretically, completely blocked
the (+)SKF-38393-induced effects on CPu cells but failed to change the
depressant effects produced by either quinpirole or 5-HT. On the other
hand, the selective D-2 antagonist I-sulpiride, blocked the effects induced
by quinpirole but not (+)SKF-38393. These observations suggest that the D-1
and D-2 DA receptor agonists elicit their effects via distinct DA receptor
subtypes. A comparison of these results with our previous results obtained
from the nucleus accumbens (NAc) indicates that NAc cells are more
responsive to DA D-2 agonist, whereas CPu cells are more sensitive to D-1
agonist. Therefore, D-1 receptors in the CPu may have a critical role in
mediating the effect produced by DA.(ABSTRACT TRUNCATED AT 400 WORDS)
This article has been cited by other articles:
|
|
|
|
 
L. Liang, M. R. DeLong, and S. M. Papa
Inversion of Dopamine Responses in Striatal Medium Spiny Neurons and Involuntary Movements
J. Neurosci.,
July 23, 2008;
28(30):
7537 - 7547.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
O. Darbin and T. Wichmann
Effects of Striatal GABAA-Receptor Blockade on Striatal and Cortical Activity in Monkeys
J Neurophysiol,
March 1, 2008;
99(3):
1294 - 1305.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. F. Perez, F. J. White, and X.-T. Hu
Dopamine D2 Receptor Modulation of K+ Channel Activity Regulates Excitability of Nucleus Accumbens Neurons at Different Membrane Potentials
J Neurophysiol,
November 1, 2006;
96(5):
2217 - 2228.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. J. Gruber, S. A. Solla, D. J. Surmeier, and J. C. Houk
Modulation of Striatal Single Units by Expected Reward: A Spiny Neuron Model Displaying Dopamine-Induced Bistability
J Neurophysiol,
August 1, 2003;
90(2):
1095 - 1114.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Yasumoto, E. Tanaka, G. Hattori, H. Maeda, and H. Higashi
Direct and Indirect Actions of Dopamine on the Membrane Potential in Medium Spiny Neurons of the Mouse Neostriatum
J Neurophysiol,
March 1, 2002;
87(3):
1234 - 1243.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. R. West and A. A. Grace
Opposite Influences of Endogenous Dopamine D1 and D2 Receptor Activation on Activity States and Electrophysiological Properties of Striatal Neurons: Studies Combining In Vivo Intracellular Recordings and Reverse Microdialysis
J. Neurosci.,
January 1, 2002;
22(1):
294 - 304.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. N. Ruskin, D. A. Bergstrom, and J. R. Walters
Multisecond Oscillations in Firing Rate in the Globus Pallidus: Synergistic Modulation by D1 and D2 Dopamine Receptors
J. Pharmacol. Exp. Ther.,
September 1, 1999;
290(3):
1493 - 1501.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
E. A. Kiyatkin and G. V. Rebec
Striatal Neuronal Activity and Responsiveness to Dopamine and Glutamate after Selective Blockade of D1 and D2 Dopamine Receptors in Freely Moving Rats
J. Neurosci.,
May 1, 1999;
19(9):
3594 - 3609.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Lavin and A. A. Grace
Dopamine Modulates the Responsivity of Mediodorsal Thalamic Cells Recorded In Vitro
J. Neurosci.,
December 15, 1998;
18(24):
10566 - 10578.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. N. Ruskin, S. S. Rawji, and J. R. Walters
Effects of Full D1 Dopamine Receptor Agonists on Firing Rates in the Globus Pallidus and Substantia Nigra Pars Compacta In Vivo: Tests for D1 Receptor Selectivity and Comparisons to the Partial Agonist SKF 38393
J. Pharmacol. Exp. Ther.,
July 1, 1998;
286(1):
272 - 281.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
F. Gonon
Prolonged and Extrasynaptic Excitatory Action of Dopamine Mediated by D1 Receptors in the Rat Striatum In Vivo
J. Neurosci.,
August 1, 1997;
17(15):
5972 - 5978.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Hernandez-Lopez, J. Bargas, D. J. Surmeier, A. Reyes, and E. Galarraga
D1 Receptor Activation Enhances Evoked Discharge in Neostriatal Medium Spiny Neurons by Modulating an L-Type Ca2+ Conductance
J. Neurosci.,
May 1, 1997;
17(9):
3334 - 3342.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Wambebe, E. Sokomba, and G. J. Amabeoku
Some behavioural effects of quinine in mice
J Psychopharmacol,
January 1, 1989;
3(3):
156 - 168.
[Abstract]
[PDF]
|
|
|
|
|
