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Journal of Neuroscience, Vol 8, 920-931, Copyright © 1988 by Society for Neuroscience
Genesis of GABA-immunoreactive neurons in the ferret visual cortex
JD Peduzzi
Department of Physiological Optics, School of Optometry, University of Alabama, Birmingham 35294.
The pattern of neurogenesis of GABA-immunoreactive neurons in the ferret
primary visual cortex was determined using immunohistochemical and
3H-thymidine autoradiographic techniques. Neurons in the visual cortex of
the ferret undergo their final cell division during a period extending from
embryonic day 20 (E20) to postnatal day 14 (P14) and follow an inside-out
pattern of neuronal production (Jackson et al., 1984) similar to that
observed in other mammals. Earlier-generated neurons are found at deeper
cortical positions in the adult than are those generated later. Layer I is
an exception to this rule, since neurons destined for this layer are
produced at both the beginning and end of neurogenesis. In this study, the
pattern of neurogenesis of GABA- immunoreactive neurons is compared to the
pattern observed for nonimmunoreactive neurons. The overall pattern of
cortical neurogenesis (inside-out pattern) is similar for
GABA-immunoreactive neurons and neurons that are not GABA-immunoreactive.
However, the GABA- immunoreactive neurons born on a given day of
development are more broadly distributed across the radial axis of the
adult cortex than are nonimmunoreactive neurons generated on the same day.
GABA- immunoreactive neurons generated later in neurogenesis are, on
average, slightly smaller than those generated early. If
GABA-immunoreactive neurons in the visual cortex are interneurons, then
these findings suggest that interneurons follow the same pattern of
neurogenesis as do projecting neurons in the visual cortex.
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