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Journal of Neuroscience, Vol 8, 2350-2360, Copyright © 1988 by Society for Neuroscience
Molecular evidence for early activity-dependent development of hamster motor neurons
RG Kalb and S Hockfield
Section of Neuroanatomy, Yale University School of Medicine, New Haven, Connecticut 06510.
Monoclonal antibody Cat-301 recognizes a surface antigen on subsets of
neurons in many areas of the mammalian CNS, including Y-cells in the cat
dorsal lateral geniculate nucleus (LGN) and spinal motor neurons in several
species. We have shown previously that the Cat-301 antigen is expressed
relatively late in postnatal development, with a time course that matches
that of late developmental features of both LGN and spinal cord neurons.
The developmental time course of the expression of the Cat-301 antigen in
the LGN correlates with the period during which visual deprivation can
alter LGN Y-cells. Neonatal visual deprivation (by monocular lid suture or
dark rearing) suppresses Cat-301 expression on Y-cells, while deprivation
in adult animals has no effect on antigen expression. These results
suggested that the onset of Cat-301 immunoreactivity provides a positive
molecular marker for the end of a critical period in cat visual system
development. To determine if Cat- 301 might be a general marker for
experience-dependent development in other areas of the CNS we have examined
antigen expression on hamster spinal cord motor neurons. Here, we report
that Cat-301 immunoreactivity develops on hamster motor neurons between
postnatal days 7 and 14. Altering neuromuscular activity by sciatic nerve
crush or thoracic hemicordotomy inhibits Cat-301 expression on motor
neurons if performed before the onset of Cat-301 immunoreactivity. Other
motor neuron antigens are unaffected by this procedure. In adult animals,
nerve crush or cordotomy has no effect on Cat-301 immunoreactivity,
demonstrating that Cat-301 expression is not simply dependent on ongoing
neural activity. These observations suggest that motor neurons, like LGN
neurons, require some pattern of neuronal activity during a critical period
in development and, further, that the phenotypic changes in neurons
consequent to early activity are reflected by the expression of specific
molecules. The identification and characterization of such molecules may
yield a description of the molecular mechanisms of experience-dependent
development.
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