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Journal of Neuroscience, Vol 9, 56-62, Copyright © 1989 by Society for Neuroscience
Habituation and dishabituation of a cleaning reflex in normal and mutant Drosophila
G Corfas and Y Dudai
Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel.
Upon tactile stimulation of its thoracic bristle(s), Drosophila cleans with
a patterned set of leg movements the field covered by the stimulated
bristles. We demonstrate that this cleaning reflex undergoes habituation
and dishabituation. Repeated monotonous stimulation of the bristles by
controlled air puffs leads to decrement, and finally to disappearance, of
leg response. Spontaneous recovery of the response takes place in a
time-dependent manner. Restoration of response can also be obtained by
application of a high-frequency stimulus directed to other bristles. A
mutant, rut, which is defective in learning and in adenylate cyclase
activity, can habituate and dishabituate, but habituation is abnormally
short-lived. As opposed to both nonassociative and associative learning
paradigms used in Drosophila to date, the cleaning reflex lends itself to
some aspects of cellular analysis, since single sensory neurons that
mediate the input and motor neurons that mediate the behavioral output are
identifiable. The modified reflex should therefore be useful in
establishing the effects of single gene mutations that affect behavioral
plasticity on the development and properties of identified neurons that
contribute to discrete modifiable behaviors.
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