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Journal of Neuroscience, Vol 9, 3760-3765, Copyright © 1989 by Society for Neuroscience
Elementary processes of response selection mediated by distinct regions of the striatum
VJ Brown and TW Robbins
Department of Experimental Psychology, University of Cambridge, United Kingdom.
The relative contributions of the medial and lateral caudate putamen to
performance of a visual reaction time task were compared by examining the
effects of unilateral ibotenate-induced lesions to these regions in the
rat. Different groups of rats were trained to respond either towards
(Discrimination 1) or away from (Discrimination 2) unpredictable, brief
visual stimuli presented to either side of the head. Lateral striatal
lesions produced a strong spatial bias towards the side of the lesion but
left the latency for the initiation of responses to the visual cues
unchanged. By contrast, the medial striatal lesions resulted in a smaller
degree of spatial response bias but a significant slowing of initiation
latency to the side contralateral to the lesion. These effects were
irrespective of the side of the stimulus presentation and thus represent
response-related impairments. The lesions were further dissociated in their
effects on responding inappropriately to task requirements. These results
demonstrate a double dissociation of behavioral effects of lateral and
medial striatal damage that can be used to infer the operation of distinct
elementary processes of response output within a single task. They are
important not only in demonstrating functional effects of hypothetical
segregated parallel corticostriatal loops but also in showing that these
loops must interact to produce integrated performance.
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