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Journal of Neuroscience, Vol 9, 565-573, Copyright © 1989 by Society for Neuroscience
Nicotinic acetylcholine receptor-like molecules in the retina, retinotectal pathway, and optic tectum of the frog
PB Sargent, SH Pike, DB Nadel and JM Lindstrom
Division of Biomedical Sciences, University of California, Riverside 92521.
Forty-two monoclonal antibodies (mAbs) generated against nicotinic
acetylcholine receptors (AChRs) from electric organ were tested for their
ability to cross-react in the optic tectum of the frog Rana pipiens.
Twenty-eight of the mAbs tested (67%) bound to the optic neuropil of the
tectum as revealed by immunoperoxidase cytochemistry. The pattern of
peroxidase stain for cross-reacting mAbs corresponded in position to a
subset of the retinotectal projections. Electron microscopic examination
revealed that peroxidase reaction product was associated with the surface
of vesicle-containing profiles but not with synaptic sites. Removal of one
retina resulted in the loss of immunoreactivity in the contralateral
tectum. AChR-like immunoreactivity was also associated with the optic tract
and optic nerve and with retinal ganglion cells. These results indicate
that some classes of retinal ganglion cells bear AChR-like molecules on
their surface. The existence of these molecules on ganglion cell axons and
terminals seems the most likely explanation for the AChR-like
immunoreactivity present in the tectum.
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