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Journal of Neuroscience, Vol 9, 2999-0318, Copyright © 1989 by Society for Neuroscience
Localization and development of nerve growth factor-sensitive rat basal forebrain neurons and their afferent projections to hippocampus and neocortex
S Koh and R Loy
Department of Neurobiology and Anatomy, University of Rochester School of Medicine, New York 14642.
In order to understand further the role of NGF in the development of
NGF-sensitive basal forebrain neurons and their afferent connections to the
hippocampus and neocortex, we have used monoclonal antibody 192 IgG to
detect and localize NGF receptors immunocytochemically in the developing
rat brain. NGF receptor immunoreactivity (NGF-RI) is first visible at
embryonic day 13 (E 13) in the ventrolateral telencephalic wall and follows
a caudal-to-rostral gradient in its initial appearance. NGF-RI neuronal
number and neuropil staining undergo substantial increases before birth,
and extensive dendritic growth and increases in perikaryal size continue
during the first 3 weeks of postnatal life. This growth and cellular
differentiation, however, is followed in the fourth postnatal week and
later by an apparent decrease in dendritic arborization and 50% shrinkage
in the size of perikarya. Initial NGF-RI fiber outgrowth from immature
basal forebrain neurons directed toward appropriate target fields is
observed as early as E 15. The formation of a laminar pattern by septal
axons in the hippocampal terminal fields and invasion of NB afferents into
the cortex occur postnatally over a protracted time. In the hippocampus,
NGF-RI is initially diffusely distributed, and wide bands of immature
granule and pyramidal cells are almost devoid of immunoreactive fibers;
however, with maturity, septal axon terminals become concentrated in narrow
zones closely associated with the cellular layers. In the neocortex,
early-arriving basal forebrain afferents accumulate in the intermediate
zone underneath the darkly immunoreactive subplate before they enter The
cortex. Dense subplate and transiently present, radially aligned fiber
staining completely disappear in later postnatal week and are gradually
replaced by specific axonal and terminal staining associated with NB
afferents. The expression of NGF receptor in the subplate zone at the time
afferents arrive and its subsequent disappearance with the specific
terminal formation suggest that NGF receptor and concomitant accumulation
of NGF in the subplate may act as a temporary target for the early-arriving
basal forebrain afferents; ingrowing afferents may then be guided by
radially oriented NGF-RI fibers to proper synaptic sites.
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