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Journal of Neuroscience, Vol 9, 3146-3168, Copyright © 1989 by Society for Neuroscience
Postsynaptic dorsal column pathway of the rat. III. Distribution of ascending afferent fibers
KD Cliffer and GJ Giesler Jr
Department of Cell Biology and Neuroanatomy, University of Minnesota, Minneapolis 55455.
The distribution in the dorsal column nuclei (DCn) of post-synaptic dorsal
column (PSDC) fibers was examined in rats following injections of Phaseolus
vulgaris leucoagglutinin (PHA-L) in the spinal cord. Lemniscal neurons in
the DCn were retrogradely labeled in the same animals by injecting the
thalamus with Fluoro-Gold. In some experiments, primary afferent fibers
were also labeled by injecting dorsal root ganglia with
choleragenoid-conjugated HRP. Injections of PHA-L into the cervical
enlargement labeled many fibers and varicosities throughout most of the
ipsilateral cuneate nucleus. Labeled fibers were also present in the
external cuneate and internal basilar nuclei. Injections of PHA-L into
thoracic cord labeled fibers and varicosities in the medial cuneate and
lateral gracile nuclei, as well as the external cuneate nucleus. Injections
into the lumbar enlargement labeled fibers and varicosities throughout most
of the gracile nucleus. Injections in sacral cord labeled fibers in the
most medial part of the gracile nucleus. Dense labeling of PSDC fibers was
found in areas with high densities of retrogradely labeled lemniscal
neurons and areas with high densities of primary afferent fibers. In all
regions of the DCn and in the external cuneate nucleus, fibers and
varicosities labeled for PHA-L were seen in apposition to retrogradely
labeled lemniscal cells. The distribution of postsynaptic afferent fibers
in the DCn of the rat and its relationship to lemniscal neurons and primary
afferent fibers contrast sharply with these features in cats.
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