 |
||||
|
||||
|
||||
|
||||
Electronic Letters to:
- Brief Communications:
Lindsey J. Macpherson, Bailong Xiao, Kelvin Y. Kwan, Matt J. Petrus, Adrienne E. Dubin, SunWook Hwang, Benjamin Cravatt, David P. Corey, and Ardem Patapoutian- An Ion Channel Essential for Sensing Chemical Damage
J. Neurosci. 2007; 27: 11412-11415[Abstract] [Full text] [PDF]
eLetters: Submit a response to this article
Electronic letters published:
Pain and inflammation
- Heikki Savolainen (18 October 2007)
Pain and inflammation 18 October 2007 
Heikki Savolainen,
Prof.
Dept. of Occup. Safety & Hlth, FIN-33101 Tampere, FinlandSend letter to journal:
Re: Pain and inflammation
heikki.savolainen{at}stm.fi Heikki Savolainen
The investigation proves the role of the ionic channel in the pain perception by formaldehyde application. Pain does not necessarily equal tissue damage which might e.g. require further neurogenic inflammation. The latter response recruits e.g. the immunocompetent cells and incites growth factor upregulation. The major mediator in this process is substance P as liberated from its inactive precursors. Its effects can be counteracted by the upregulation of the dipeptidylpeptidase IV (1). Thus, it seems that the pain perception is associated with a sensory peptidergic hyperfunction that initiates the inflammatory response. It would be very interesting to probe this association further.
1 Grouzmann E, Monod M, Landis B et al. Loss of dipeptidylpetidase IV activity in chronic rhinosinusitis contributes to the neurogenic inflammation induced by substance P. FASEB J 2002; express article 10.1096/fj.01-0939fje
|
|
|
|
 |
|