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Electronic Letters to:
- Brief Communications:
Xinghua Yin, Grahame J. Kidd, Klaus-Amin Nave, and Bruce D. Trapp- P0 Protein Is Required for and Can Induce Formation of Schmidt-Lantermann Incisures in Myelin Internodes
J. Neurosci. 2008; 28: 7068-7073[Abstract] [Full text] [PDF]
eLetters: Submit a response to this article
Electronic letters published:
Roles of myelin protein species
- Heikki Savolainen (22 July 2008)
Roles of myelin protein species 22 July 2008 
Heikki Savolainen,
Prof.
Dept. of Occup. Safety & Hlth, POB 536, FIN-33101 Tampere, FinlandSend letter to journal:
Re: Roles of myelin protein species
heikki.savolainen{at}stm.fi Heikki Savolainen
This elegant paper adds a new view on the incisures in myelin internodes. It should be reconciled with the known composition of the myelin protein structure, i.e. there is much less proteolipid protein in the peripheral nervous system (PNS) myelin than in that isolated from central nervous system (Savolainen, 1972), and the major PNS myelin protein is also a glycoprotein. Therefore, if the glycopeptides act as receptors or bonds, the results are plausible. However, it would be interesting to probe the transition area in the nerve roots where PNS-type myelin takes over from the oligodendrocyte-synthesized myelin. It is known that Schwann cells can migrate and remyelinate axons in roots devoid of central nervous system myelin.
Savolainen H. Proteins and glycoproteins of human myelin and glial cell membrane with special reference to myelin formation. T-I-T J Life Sci 1972; 2: 35-38
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