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Electronic Letters to:
- Cellular:
Fahima Mayer, Nasima Mayer, Leslie Chinn, Robert L. Pinsonneault, Deanna Kroetz, and Roland J. Bainton- Evolutionary Conservation of Vertebrate Blood–Brain Barrier Chemoprotective Mechanisms in Drosophila
J. Neurosci. 2009; 29: 3538-3550[Abstract] [Full text] [PDF]
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Electronic letters published:
BBB in toxicology
- Heikki Savolainen (19 March 2009)
BBB in toxicology 19 March 2009 
Heikki Savolainen,
Prof.
Dept. of Occup. Safety & Hlth., POB 536, FIN-33101 Tampere, FinlandSend letter to journal:
Re: BBB in toxicology
heikki.savolainen{at}stm.fi Heikki Savolainen
Dear Editor,
This investigation offers an excellent method to study blood-brain barrier (BBB). The transporters can also malfunction. L- lactate is an energy source for brain and therefore taken up by the monocarboxylate transporter (MCT). However, the MCT does not differentiate between D- and L-isomers. D-Lactate is only slowly metabolized so that it is toxic even at modest concentrations.
The BBB can also be saturated at high doses of toxicants. Lead at blood levels higher than 1 mg/l enters the cerebrospinal spaces more readily (1) resembling that in infants and children with immature BBB functions.
1 Savolainen H, Kilpiö J. Brain and blood lead in acute intoxication. Scand j Work Environ Hlth 1977; 3: 104-7
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