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Electronic Letters to:
- Cellular:
Thien Nguyen, Niraj R. Mehta, Katherine Conant, Kee-Jun Kim, Melina Jones, Peter A. Calabresi, Giorgia Melli, Ahmet Hoke, Ronald L. Schnaar, Guo-Li Ming, Hongjun Song, Sanjay C. Keswani, and John W. Griffin- Axonal Protective Effects of the Myelin-Associated Glycoprotein
J. Neurosci. 2009; 29: 630-637[Abstract] [Full text] [PDF]
eLetters: Submit a response to this article
Electronic letters published:
Demyelination in the CNS and PNS
- Heikki Savolainen (29 January 2009)
Demyelination in the CNS and PNS 29 January 2009 
Heikki Savolainen,
Prof.
Dept. of Occup. Safety & Hlth, POB 536, FIN-33101 Tampere, FinlandSend letter to journal:
Re: Demyelination in the CNS and PNS
heikki.savolainen{at}stm.fi Heikki Savolainen
This exciting study casts light on the role(s) of MAG in maintaining axons. However, direct comparison of demyelination in brain in multiple sclerosis with demyelination in peripheral nerves is a complex task. Peripheral myelin is made by Schwann cells, whereas CNS myelin is made by oligodendroglial cells. The biology of these cell types is completely different and so are the myelin protein species (1).
The destruction of myelin protein in MS (2) is different from that of demyelination in, for example, diabetic neuropathy, a peripheral condition (3).
1 Savolainen H, Proteins and glycoproteins of human myelin and glial cell membranes with special reference to myelin formation. TIT J Life Sci 1972; 2: 35-8
2 Riekkinen PJ, Palo J, Arstila AU, Savolainen H, et al. Protein composition of multiple sclerosis myelin. Arch Neurol (Chic) 1971; 24: 545 -9
3 Palo J, Savolainen H, Haltia M. Proteins of peripheral nerve myelin in diabetic neuropathy. J Neurol Sci 1972; 16: 193-9.
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