 |
|||||
|
|||||
|
|||||
|
|||||
|
|||||
Electronic Letters to:
- Cellular:
Kate Lykke Lambertsen, Bettina Hjelm Clausen, Alicia Anne Babcock, Rikke Gregersen, Christina Fenger, Helle Hvilsted Nielsen, Laila Skov Haugaard, Martin Wirenfeldt, Marianne Nielsen, Frederik Dagnaes-Hansen, Horst Bluethmann, Nils Joakim Færgeman, Michael Meldgaard, Tomas Deierborg, and Bente Finsen- Microglia Protect Neurons against Ischemia by Synthesis of Tumor Necrosis Factor
J. Neurosci. 2009; 29: 1319-1330[Abstract] [Full text] [PDF]
eLetters: Submit a response to this article
Electronic letters published:
TNF-alpha: Neurotoxic or neuroprotective in stroke
- Rao M Adibhatla, James F Hatcher (5 February 2009)
TNF-alpha: Neurotoxic or neuroprotective in stroke 5 February 2009 
Rao M Adibhatla,
Assistant Professor
Univ. of Wisconsin Sch. Med. & Public Health, Dept. of Neurological Surgery, Madison , WI 53792,
James F HatcherSend letter to journal:
Re: TNF-alpha: Neurotoxic or neuroprotective in stroke
adibhatl{at}neurosurg.wisc.edu Rao M Adibhatla, et al.
We read with interest the article by Lambertsen et al. (2009) showing that TNF-alpha null mice showed exacerbated ischemic injury volume and behavioral deficits after 24 hr permanent middle cerebral artery occlusion. The pleiotropic nature of TNF-alpha has been documented by various research groups (Bruce et al., 1996; Rothwell and Luheshi, 1996; Martin-Villalba et al., 2001; Hallenbeck, 2002). However, these findings seem to contradict an earlier report demonstrating significantly reduced infarct volume (Martin-Villalba et al., 2001) in TNF-alpha null mice (Marino et al., 1997). Even granted the differences in ischemia models (permanent vs. transient MCAO), it would have benefited readers if the authors had addressed this discrepancy: why one TNF-alpha knockout shows increased injury (Lambertsen et al., 2009) while another TNF-alpha knockout shows reduced injury (Martin-Villalba et al., 2001). It is conceivable that compensatory changes in other cytokines such as interleukin-1beta might account for these differences (Clausen et al., 2008), however, the status of other cytokines in the TNF-alpha null mice is unknown.
Bruce AJ, Boling W, Kindy MS, Peschon J, Kraemer PJ, Carpenter MK, Holtsberg FW, Mattson MP (1996) Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors. Nat Med 2:788-794.
Clausen B, Lambertsen K, Babcock A, Holm T, Dagnaes-Hansen F, Finsen B (2008) Interleukin-1b and tumor necrosis factor-a are expressed by different subsets of microglia and macrophages after ischemic stroke in mice. J Neuroinflammation 5:46.
Hallenbeck JM (2002) The many faces of TNF in stroke. Nat Med 8:1363- 1368.
Lambertsen KL, Clausen BH, Babcock AA, Gregersen R, Fenger C, Nielsen HH, Haugaard LS, Wirenfeldt M, Nielsen M, Dagnaes-Hansen F, Bluethmann H, Faergeman NJ, Meldgaard M, Deierborg T, Finsen B (2009) Microglia protect neurons against ischemia by synthesis of tumor necrosis factor. J Neurosci 29:1319-1330.
Marino MW, Dunn A, Grail D, Inglese M, Noguchi Y, Richards E, Jungbluth A, Wada H, Moore M, Williamson B, Basu S, Old LJ (1997) Characterization of tumor necrosis factor-deficient mice. Proc Natl Acad Sci USA 94:8093-8098.
Martin-Villalba A, Hahne M, Kleber S, Vogel J, Falk W, Schenkel J, Krammer PH (2001) Therapeutic neutralization of CD95-ligand and TNF attenuates brain damage in stroke. Cell Death Differ 8:676-686.
Rothwell NJ, Luheshi GN (1996) Brain TNF: damage limitation or damaged reputation? Nat Med 2:746-747.
|
|
|
|
 |
|