Fig. 7. PKCδ-immunoreactive cells in the rat brain 2 d after 90 min of ischemia. On the contralateral side of the frontoparietal (A) and cingulate (B,left) cortex, only a few immunoreactive neurons are seen, whereas in corresponding areas on the ipsilateral side (B, right; C), a large population of cortical neurons are immunoreactive. In cortical neurons, immunolabeling is extranuclear (D). In the contralateral striatum, numerous immunoreactive bundles of nerve fibers are seen (E). In the ipsilateral striatum (F), these nerve fibers have disappeared in the ischemic core (c), but have become strongly immunoreactive in the perifocal zone (p). In the infarct core, immunoreactive material is seen around small blood vessels, presumably in endothelial cells (G, curved arrows) and in glial-like cells (H). Scale bars: A–C, E, F, 250 μm; D, 25 μm; G, 125 μm; H, 50 μm.