The Role of Monoamine Metabolism in Oxidative Glutamate Toxicity

This research was supported by grants from National Institutes of Health (NS28121, P.M.) and European Molecular Biology Organization (J.D.). J.D. was also supported by a National Institutes of Health grant (RO1 NS09658) to David Schubert. We thank Drs. J. Trotter, C. Behl, X. O. Breakefield, and especially D. Schubert for technical assistance and helpful discussion. We also thank R. Lesley for performing some of the H₂O₂ assays and B. Liu for preparing the mitochondria.

Correspondence should be addressed to Dr. P. Maher, The Scripps Research Institute, 10666 North Torrey Pines Road, La Jolla, CA 92037.

Dr. Davis’s present address: Department of Molecular Neuropathology, SmithKline Beecham, Harlow CM19 5AD, UK.