Article Information
- Received October 10, 1996
- Revision received November 25, 1996
- Accepted November 26, 1996
- First published February 15, 1997.
- Version of record published February 15, 1997.
Author Information
- A. Jones1,FNa,
- E. R. Korpi2,FNa,
- R. M. McKernan3,FNa,
- R. Pelz4,FNa,
- Z. Nusser5,
- R. Mäkelä2,
- J. R. Mellor1,
- S. Pollard6,
- S. Bahn1,
- F. A. Stephenson6,
- A. D. Randall1,
- W. Sieghart4,
- P. Somogyi5,
- A. J. H. Smith1, and
- W. Wisden1
- 1Medical Research Council Laboratory of Molecular Biology, Medical Research Council Centre, Cambridge CB2 2QH, United Kingdom,
- 2Department of Pharmacology and Clinical Pharmacology, University of Turku, Fin-20014 Turku, Finland, Department of Alcohol Research, National Public Health Institute, Fin-00180 Helsinki, Finland,
- 3Merck Sharp & Dohme Research Laboratories, Neuroscience Research Centre, Harlow, CM20 2QR, United Kingdom,
- 4University Clinic for Psychiatry, Department of Biochemical Psychiatry, 1090 Vienna, Austria,
- 5Medical Research Council Anatomical Neuropharmacology Unit, Oxford University Department of Pharmacology, Oxford, OX1 3TH, United Kingdom, and
- 6School of Pharmacy, University of London, Brunswick Square, London, WC1N 1AX, United Kingdom
Author contributions
Disclosures
- Received October 10, 1996.
- Revision received November 25, 1996.
- Accepted November 26, 1996.
↵FNa These authors made equally important contributions to different aspects of this work.
S.B. holds a European Community Human Capital and Mobility Fellowship (category 20). A.J.H.S. was supported by the Association for International Cancer Research. This work was supported in part by EC Grant BIO4-CT96-0585 to P.S. and W.S. We thank Terry Rabbitts, Theresa Langford, and Gareth King (Laboratory of Molecular Biology, Cambridge) for providing invaluable support and guidance with transgenic mice; Grayson Richards (F. Hoffman-LaRoche, Basel) for supplying Ro 15-1788; and Pirkko Johansson, Maija Sarviharju, and Antti Turhala (Department of Alcohol Research, National Public Health Institute, Helsinki) and Frances Emms (Merck Sharp and Dohme, Harlow) for technical help with behavior, autoradiography, and ligand binding. We are grateful to Gregg E. Homanics (Department of Anesthesiology, University of Pittsburgh) for communicating data on his α6 knock-out mouse line before publication. Hilmar Bading, Louise Tierney, Stephen Hunt, Trevor Smart, and Nigel Unwin provided helpful comments on this manuscript.
Correspondence should be addressed to W. Wisden, Medical Research Council Laboratory of Molecular Biology, Medical Research Council Centre, Hills Road, Cambridge, CB2 2QH, UK.
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