Fig. 1. MAG-deficient sciatic nerves contain degenerating myelin internodes and redundant myelin.A–D, Epon sections of sciatic nerves from P35 (A = MAG+/+, B = MAG−/−) and 3-month-old mice (C = MAG+/+,D = MAG−/−). Occasional MAG-deficient myelinated fibers are degenerating (B, D,arrows), and some axons are surrounded by redundant or excessive myelin (B, D,arrowheads). E–H, At 9 months (E = MAG+/+, F = MAG−/−) and 16 months (G = MAG+/+,H = MAG−/−) of age, degenerating myelin internodes (arrows) and redundant myelin (arrowheads) persist in MAG-deficient sciatic nerves. Compared with control nerves, myelinated fibers in MAG-deficient nerves appear to have reduced axonal calibers. Scale bar, 10 μm.