Structure and Dynamics of the GABA Binding Pocket: A Narrowing Cleft that Constricts during Activation

This work was supported in part by National Institute of Neurological Disorders and Stroke Grants NS10579 (to D.W.) and NS34727 (to C.C.). C.C. is a recipient of the Burroughs Welcome Fund New Investigator Award in the Basic Pharmacological Sciences. We thank Amy Kucken, Jeremy Teissére, Dr. Andrew Boileau, Dr. Meyer Jackson, and Dr. Matt Jones for critical reading of this manuscript.

Correspondence should be addressed to Dr. Cynthia Czajkowski, University of Wisconsin, Department of Physiology, Room 197 MSC, 1300 University Avenue, Madison, WI 53706. E-mail:czajkowski{at}physiology.wisc.edu.