Functional Analysis of Capsaicin Receptor (Vanilloid Receptor Subtype 1) Multimerization and Agonist Responsiveness Using a Dominant Negative Mutation

This study was supported by National Institutes of Health Grants NS18788 and NS39420 to G.S.O. and by a Howard Hughes Pilot Studies grant to E.V.K. We thank Rakhshi Khan and Suman Vidyarthyi for technical assistance in generating the VR1 mutations and cell lines. In addition, we thank Doug Krafte and David Printzenhoff (ICAgen, Inc.) for help with the FLIPR experiments.

Correspondence should be addressed to Dr. Gerry S. Oxford, Department of Cell and Molecular Physiology, University of North Carolina, Box 7545, 452 Medical Science Research Building, Chapel Hill, NC 27599. E-mail: gsox{at}med.unc.edu.