Article Information
- Received February 19, 2002
- Revision received May 15, 2002
- Accepted May 31, 2002
- First published September 15, 2002.
- Version of record published September 15, 2002.
Author Information
- Cheryl L. Wellington1,
- Lisa M. Ellerby2,
- Claire-Anne Gutekunst3,
- Danny Rogers1,
- Simon Warby1,
- Rona K. Graham1,
- Odell Loubser1,
- Jeremy van Raamsdonk1,
- Roshni Singaraja1,
- Yu-Zhou Yang1,
- Juliette Gafni2,
- Dale Bredesen2,
- Steven M. Hersch4,
- Blair R. Leavitt1,
- Sophie Roy5,
- Donald W. Nicholson5, and
- Michael R. Hayden1
- 1Centre for Molecular Medicine and Therapeutics, British Columbia Children's and Women's Hospital, Vancouver, British Columbia, Canada V5Z 4H4,
- 2Buck Institute for Research in Aging, Novato, California 94945,
- 3Department of Neurology, Emory University, Atlanta, Georgia 30322,
- 4Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, and
- 5Merck Frosst Centre for Therapeutic Research, Montreal, Quebec, Canada H9R 4P8
Author contributions
Disclosures
- Received February 19, 2002.
- Revision received May 15, 2002.
- Accepted May 31, 2002.
This work was supported by National Institutes of Health (NIH) Grant NS40251 (L.M.E.), the Huntington's Disease Society of America, and the Multiple Dystrophy Association. C.-A.G. and D.B. are supported by the NIH. S.M.H. is supported by NIH Grants NS35255 and AT00613, the Hereditary Disease Foundation (HDF), and the Huntington Disease Society of America (HDSA). M.R.H. is supported by a Merck Frosst Grant to the Centre for Molecular Medicine and Therapeutics, the Canadian Institutes of Health Research, the Canadian Networks of Centres of Excellence and is a holder of a Canada Research Chair. We thank members of our respective laboratories for their support and critical evaluation of the data. We also thank the Canadian Brain Tissue Bank, the Harvard Brain Tissue Resource Center, and the HDF for generously sharing rare HD tissue. We thank the HDSA and the HDF for their generous support of this work.
∗C.L.W. and L.M.E. contributed equally to this work.
Correspondence should be addressed to Michael R. Hayden, Centre for Molecular Medicine and Therapeutics, 980 West 28th Avenue, Vancouver, British Columbia, Canada V5Z 4H4. E-mail: mrh{at}cmmt.ubc.ca.
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