Figure 3.
Accelerated developmental decline of WM-LTP in enriched mice. A, Average time course of the changes in layer III field synaptic potential amplitude after TBS of the WM in EC (black) and SC (white) mice at different postnatal ages (P13; p > 35). The bars indicate SEM. Averages of 10 consecutive traces recorded at different postnatal ages from EC and SC mice before (thin line) and 30 min after (thick line) TBS are also reported on the top of the time course for each age. B, Postnatal age-dependent changes in the magnitude of WM-LTP measured 30 min after TBS. Three-way ANOVA shows that, although the time course of the field potential amplitude is the same in all conditions (F(12) = 0.37; p = 0.9), the level of potentiation is significantly different at different ages and for the two different groups (F(13) = 2.67, p < 0.001, and F(11) = 29.91, p < 0.001, respectively). Moreover, the three-way ANOVA shows a significant interaction between the postnatal age and the environmental housing (F(13, 11) = 3.79; p = 0.01), with the EC group being significantly different from the SC group at P20 (post hoc LSD test; p < 0.05). The bars indicate SEM.