Figure 3.
HVA Ca2+ currents in acutely isolated thalamic relay neurons. A, Much larger T-currents, which are rapidly inactivated, were obtained from TC neurons in α1A–/–/α1G+/+ than from control (α1A+/+/α1G+/+), whereas T-currents were nearly absent in the α1A–/–/α1G–/– TC neurons. B, The histogram shows the mean peak amplitude of T-type Ca2+ current in acutely isolated TC neurons from control (black bars), α1A–/–/α1G+/+ (gray bars), α1A–/–/α1G+/– (dark gray bars), and α1A–/–/α1G–/– (white bars). C, The histogram indicates the mean peak T-type Ca2+ current densities that were from the same cells used for the histogram (B) in each group. The asterisks indicate the significant difference between each mutant and control (*p < 0.05; two-tailed t test).