Figure 3.
Group means for total ambulations, fine movements, and rearings across time after treatment with saline or 2.5, 5, 10, or 20 mg/kg doses of memantine. a, For total ambulations (whole-body movements), animals treated with 10 or 20 mg/kg showed significant (∗) hypoactivity at the beginning of the test compared with saline controls. The numbers of total ambulations steadily decreased throughout the remainder of the test session in the saline and 2.5 and 5 mg/kg memantine Mem) groups. In contrast, the 10 and 20 mg/kg memantine groups showed progressive increases in activity, the latter group being significantly higher than saline controls at both 60 and 90 min, and the former only at 90 min. b, Memantine produced similar changes in activity levels with regard to fine movements, except that differences were more extreme between the 10 and 20 mg/kg memantine groups and saline controls at the later time points, and the 5 mg/kg memantine group had significantly fewer fine movements compared with saline controls at 10 min after treatment. c, The three lowest doses of memantine significantly decreased rearing at 10 min after treatment compared with the saline controls, although all four groups exhibited similar levels of decreased rearing throughout the rest of the test period. Numbers of rearings remained relatively high throughout the test session in the animals treated with 20 mg/kg memantine such that they showed significantly elevated levels at 60 and 90 min after treatment. ∗p < 0.0125, Bonferroni’s corrected level.