Hippocampal neuron IK | | | | | |
Control | +16.7 ± 0.6 | 17.2 ± 0.5 | −25.7 ± 0.5 | 9.6 ± 0.4 | 6 |
Plus CCh | −6.5 ± 0.4a | 13.2 ± 0.4 | −54.5 ± 0.6a | 9.3 ± 0.6 | 6 |
Plus CCh (Ca2+-free external) | −2.7 ± 0.4a | 14.5 ± 0.4 | −54.1 ± 0.4a | 8.6 ± 0.6 | 3 |
Plus FK520 plus CCh | +14.4 ± 0.6 | 16.4 ± 0.5 | −28.2 ± 0.4 | 9.4 ± 0.5 | 4 |
COS-Kv2.1 | | | | | |
Control | +1.4 ± 0.4 | 15.9 ± 0.3 | −29.5 ± 0.3 | 7.7 ± 0.3 | 6 |
Plus AP | −21.3 ± 0.7a | 14.4 ± 0.6 | −55.0 ± 0.1a | 8.2 ± 0.4 | 6 |
HEK-Kv2.1 | | | | | |
Control | +16.4 ± 0.6 | 15.1 ± 0.6 | −26.2 ± 0.4 | 7.6 ± 0.3 | 8 |
Plus AP | −19.2 ± 0.9a | 13.9 ± 0.8 | −61.0 ± 0.3a | 7.3 ± 0.1 | 7 |
Plus Inm | −9.4 ± 0.7a | 11.8 ± 0.6 | −59.0 ± 0.3a | 7.3 ± 0.1 | 7 |
Plus Inm (in Ca2+-free external) | +14.1 ± 0.6 | 15.2 ± 0.5 | −29.2 ± 0.7 | 7.4 ± 0.3 | 5 |
Plus FK520 plus Inm | +14.6 ± 0.9 | 16.1 ± 0.5 | −28.4 ± 0.7 | 8.1 ± 0.5 | 6 |
Plus CCh | −9.0 ± 0.5a | 12.7 ± 0.4 | −60.2 ± 0.5a | 9.9 ± 0.2 | 8 |
Plus FK520 plus CCh | +15.1 ± 0.7 | 16.4 ± 0.6 | −27.2 ± 0.5 | 7.8 ± 0.3 | 5 |
Plus BAPTA plus CCh | +17.6 ± 0.6 | 16.3 ± 0.4 | −25.8 ± 0.5 | 7.2 ± 0.5 | 6 |
Plus 2-APB plus CCh | +13.1 ± 0.8 | 16.8 ± 0.7 | −30.2 ± 1.1 | 8.3 ± 0.6 | 4 |
Plus FK520 | +15.8 ± 0.5 | 15.5 ± 0.7 | −26.4 ± 0.8 | 7.5 ± 0.4 | 5 |