5-HTT−/− |
Saline 2 weeks |
Amounts (min) | 618.8 ± 14.4 | 667.4 ± 19.5 | 679.7 ± 11.4 | 627.5 ± 16.9 | 141.5 ± 4.5** | 145.0 ± 4.6** |
Episodes (absolute value) | 373.9 ± 21.8** | 277.0 ± 24.1*** | 597.9 ± 15.1 | 381.6 ± 22.1*** | 157.3 ± 5.2** | 122.0 ± 10.0**,*** |
n | 6 | 4 | 6 | 4 | 6 | 4 |
pCPA 2 weeks |
Amounts (min) | 641.0 ± 24.8 | 723.2 ± 27.1*** | 688.7 ± 24.3 | 618.2 ± 29.6*** | 110.4 ± 4.7* | 98.0 ± 3.1** |
Episodes (absolute value) | 318.2 ± 23.2 | 259.7 ± 12.3*** | 580.8 ± 28.4 | 365.2 ± 24.1*** | 107.9 ± 7.0* | 89.3 ± 3.2* |
n | 9 | 4 | 9 | 4 | 9 | 4 |
WAY 100635 2 weeks |
Amounts (min) | 698.9 ± 11.4* | 716.7 ± 62.8 | 600.2 ± 12.4* | 589.3 ± 62.3 | 141.0 ± 4.8 | 134.0 ± 3.5 |
Episodes (absolute value) | 356.2 ± 24.7 | 256.2 ± 20.9*** | 578.4 ± 10.9 | 384.5 ± 46.7*** | 145.0 ± 10.9 | 104.6 ± 7.6*** |
n | 5 | 4 | 5 | 4 | 5 | 4 |
Saline 4 weeks |
Amounts (min) | 588.1 ± 27.5 | 682.5 ± 18.9*** | 712.8 ± 29.1 | 612.3 ± 17.1*** | 139.1 ± 4.3** | 145.2 ± 3.3** |
Episodes (absolute value) | 357.3 ± 20.6** | 288.7 ± 23.6** | 651.2 ± 25.7 | 383.4 ± 29.3*** | 167.7 ± 8.1** | 135.1 ± 6.2**,*** |
n | 6 | 7 | 6 | 7 | 6 | 7 |
WAY 100635 4 weeks |
Amounts (min) | 582.0 ± 38.1 | 674.6 ± 27.5*** | 738.8 ± 36.1 | 642.7 ± 27.9*** | 119.3 ± 3.4* | 122.7 ± 1.0* |
Episodes (absolute value) | 377.9 ± 21.9 | 281.7 ± 23.9*** | 661.0 ± 42.8 | 427.0 ± 31.6*** | 134.5 ± 13.8* | 113.4 ± 7.3 |
n | 6 | 7 | 6 | 7 | 6 | 7 |
5-HTT+/+ |
Saline 2 weeks |
Amounts (min) | 637.2 ± 20.0 | 707.1 ± 31.1*** | 705.9 ± 29.0 | 634.3 ± 23.8*** | 96.9 ± 4.0 | 97.9 ± 2.2 |
Episodes (absolute value) | 294.5 ± 39.1 | 231.5 ± 31.7*** | 598.4 ± 28.0 | 338.4 ± 37.6*** | 86.0 ± 7.9 | 85.0 ± 9.7*** |
n | 4 | 4 | 4 | 4 | 4 | 4 |
pCPA 2 weeks |
Amounts (min) | 594.1 ± 10.7 | 749.0 ± 24.9*** | 748.6 ± 14.1 | 610.3 ± 23.9*** | 97.3 ± 5.7 | 80.7 ± 1.1*,*** |
Episodes (absolute value) | 286.5 ± 24.6 | 224.0 ± 34.8 | 590.5 ± 26.4 | 253.7 ± 23.8*** | 86.5 ± 7.1 | 69.0 ± 7.1*** |
n | 4 | 3 | 4 | 3 | 4 | 3 |
Saline 4 weeks |
Amounts (min) | 667.7 ± 32.5 | 716.3 ± 18.5 | 665.3 ± 28.1 | 629.2 ± 17.1 | 106.9 ± 7.9 | 94.4 ± 6.7 |
Episodes (absolute value) | 245.5 ± 17.5 | 181.5 ± 12.3*** | 594.2 ± 33.7 | 378.5 ± 49.5*** | 117.2 ± 20.1 | 70.4 ± 11.7*** |
n | 4 | 4 | 4 | 4 | 4 | 4 |
WAY 100635 4 weeks |
Amounts (min) | 708.5 ± 32.5 | 773.8 ± 31.7 | 631.5 ± 30.8 | 572.1 ± 28.1 | 100.0 ± 5.0 | 94.1 ± 4.9 |
Episodes (absolute value) | 310.4 ± 28.4 | 194.7 ± 37.6*** | 602.7 ± 47.9 | 263.5 ± 38.6*** | 125.8 ± 15.3 | 74.2 ± 6.7*** |
n | 5 | 4 | 5 | 4 | 5 | 4 |