Article Figures & Data
Figures
- Figure 1.
Matching-to-place performance for IL-6+/+ mice that received LPS (black line) or saline (gray line) 4 h before test session 3. A, Distance swam to platform across testing days. B, Latency to find the platform across testing days. C, Swim speed. Data are presented as mean±SEM. The arrow designates day of treatment. *Significant difference between groups as determined by Fisher's protected least-significant difference (p < 0.05).
- Figure 2.
Matching-to-place performance for IL-6+/+ mice that received a single intraperitoneal injection of LPS (100 μg; black line) or saline (gray line) 4 h before test session 9. A, Distance swam to platform across testing days. B, Latency to find the platform across testing days. C, Swim speed. Data are presented as mean±SEM. *Significant difference between groups as determined by Fisher's protected least-significant difference (p < 0.05).
- Figure 3.
Matching-to-place performance for IL-6+/+ (square symbols) and IL-6−/− (diamond symbols) mice that received a single intraperitoneal injection of LPS (black lines) or saline (gray lines) 4 h before test session 9. A, Distance swam to platform across testing days. B, Latency to find the platform across testing days. C, Swim speed. Data are presented as mean±SEM. The arrow designates day of treatment. *Significant difference between groups as determined by Fisher's protected least-significant difference (p < 0.05).
- Figure 4.
Plasma cytokine levels for IL-6+/+ (solid filled bars) and IL-6−/− (striped bars) mice that received a single intraperitoneal injection of LPS (black-filled bars) or saline (gray-filled bars) 4 h before kill. A, IL-1β. B, TNF-α. C, IL-6. D, IL-10. Data are presented as mean±SEM. nd, Cytokine levels were nondetectable. *Significant difference between groups as determined by Fisher's protected least-significant difference (p < 0.05).
- Figure 5.
A–D, Laser capture microdissection of the hippocampal neuronal layer. A–D, Stained section (A), captured neuronal layer (B), section with removed hippocampus (C), and isolated hippocampal neuronal layer (D). E, F, Percent fold change for mRNA cytokine levels for IL-6+/+ (solid filled bars) and IL-6−/− (striped bars) mice that received a single intraperitoneal injection of LPS (black-filled bars) or saline (gray-filled bars) 4 h before kill. IL-1β mRNA (E) and TNF-α (F). Data are presented as mean±SEM. nd, Cytokine levels were nondetectable. *Significant difference between groups as determined by Fisher's protected least-significant difference (p < 0.05).
- Figure 6.
A, Representative photomicrographs of c-Fos immunoreactivity in the NTS region for IL-6+/+ (top panels) and IL-6−/− (bottom panels) mice that received a single intraperitoneal injection of LPS (left panels) or saline (right panels) 4 h before sacrifice. B, Number of c-Fos-positive cells observed in the NTS. LPS induced Fos immunoreactivity similarly in both genotypes. Data are presented as mean±SEM. AP, Area postrema; CC, central canal. Scale bar, 50 mm.
