Figure 1.
Critical period for pairing induced LTP and LTD of WM→IV. A, LTP by pairing (0 mV) in cells from dark-reared mice aged P8–P12 (open circles; n = 8 mice, 15 slices), P18–P23 (gray triangles; n = 5 mice, 12 slices), and P18–P23 (filled circles; n = 4,8), and cells recorded with DNDS-containing electrodes (inverted triangles; n = 4 mice, 7 slices). B, Developmental changes in the magnitude of LTP. Individual experiments are represented as open circles. Filled circles represent data from dark-reared animals. The gray line represents a running average made over 5 d centered on each plotted age data point. Black lines show the 95% confidence interval. C, LTD induced by pairing (−40 mV) in cells from dark-reared mice aged P8–P12 (open circles; n = 12 mice, 20 slices), P18–P23 (gray triangles; n = 10 mice, 17 slices), P25–P31 (inverted triangles; n = 6 mice, 10 slices), and P28–P31 (filled circles; n = 3,6). D, Developmental changes in the LTD magnitude. Open circles, Individual experiments; gray line, running averages (5 d). Traces in A and C are the averages of 10 consecutive responses recorded just before (thin line) and 28 min after conditioning (thick line) in cells from normal-reared animals of the indicated ages.