Figure 1.
Effect of intracerebroventricular administration of NF-κB inhibitors after reexposure to the training context. A, Effect of the IKK inhibitor sulfasalazine. Top diagram, Design of the experiment. TR, Training with a footshock; T1, reactivation session; T2–T5, successive testing sessions with 24 h intervals; the injections were performed immediately after T1 (memory reactivation). The graph represents the latencies to step-through expressed as medians and interquartile ranges of animals injected with vehicle (N = 10), 3.5 mm (N = 10), or 7 mm sulfasalazine (Sulfa) (N = 12). **p < 0.01; *p < 0.05 when compared with its respective test session of the vehicle-treated group (Mann–Whitney U test, two-tailed). B, Effect of indomethacin. Top diagram, Design of the experiment. The injections were performed immediately after T1 (memory reactivation). The graph is as in A. N = 10 for each group. C, Effect of Decoy. Top diagram, Design of the experiment. TR, Training with a footshock; T1, reactivation session; T2–T6, successive testing sessions with 24 h intervals; the injections were performed immediately after reactivation. Each bar represents the medians and interquartile ranges. Mice were injected either with vehicle (N = 7), mDecoy (N = 8), or Decoy (N = 12). **p < 0.01 compared with its respective test session of the vehicle and mDecoy-treated groups (Mann–Whitney U test, two-tailed).