Figure 3.
Effects of subthalamic nucleus high-frequency stimulation on l-DOPA-induced AIMs. Analysis of AIMs was performed in the DOPA group at day 14 (□) and day 19 (○), corresponding in the DOPA+HFS group to the time points prestimulation (■) and 5 d of stimulation (•), respectively. A, Time course of the total AIM score (sum of locomotive, axial, orolingual, and forelimb scores, each rated in a scale from 0 to 4; maximum score 16) per monitoring session (1 min every 10 min over 2 h). B, Locomotive AIM, expressed in number of contralateral rotations per minute and dyskinesia score (C), corresponding to the sum of the axial, orolingual, and forelimb AIM scores (maximum 12). Four windows are considered in the 2 h monitoring period, each corresponding to the mean of the values obtained in three recording sessions. The data are the means ± SEM from six l-DOPA and five DOPA plus HFS animals. Paired t test comparisons are performed between day 14 and day 19 values in the DOPA group and between prestimulation and 5 d stimulation values in the DOPA+HFS group. *p < 0.05 compared with prestimulation values.