Figure 5.
Relieving effects of AR-C69931MX in rats with tactile allodynia. A, B, Seven day postoperative rats showing strong tactile allodynia were subjected to verification of the analgesic effect induced by intrathecal administration of drugs. Vehicle (n = 6), AR-C69931MX (0.5, 5, and 50 pmol; n = 5–7), MRS2211 (500 pmol; n = 4), or MRS2179 (50 pmol; n = 3) was injected intrathecally, and PWT was measured. C, Fourteen day postoperative rats showing strong tactile allodynia were subjected to verification of the analgesic effect induced by P2Y12 blocking agents. Vehicle (n = 3) or AR-C69931MX (50 pmol; n = 5) was injected intrathecally, and PWT was measured. Each data point represents the mean ± SEM of PWT ($,#,*p < 0.05; 0.5, 5, and 50 pmol-treated groups vs the vehicle group by multiple comparison by Tukey's test after a repeated-measure two-way ANOVA).