Home-cage activity |
Activity value (unitb) |
Light phase | Control | 5468 ± 398 | 5012 ± 598 | 4621 ± 277 | 5595 ± 321 |
| Mutant | 4505 ± 385 | 4191 ± 346 | 4582 ± 657 | 5458 ± 565 |
Dark phase | Control | 27970 ± 1761 | 22350 ± 1976 | 22782 ± 1436 | 19335 ± 1117 |
| Mutant | 22754 ± 1425* | 23176 ± 1535 | 22744 ± 2057 | 21239 ± 1867 |
Open field (low light) |
Total distance (cm) | Control | 6002 ± 252 | 5196 ± 261 | 5775 ± 293 | 6564 ± 454 |
| Mutant | 5689 ± 230 | 4883 ± 248 | 5551 ± 289 | 5694 ± 213 |
Time in center (%) | Control | 10.45 ± 1.06 | 6.72 ± 1.12 | 11.20 ± 1.64 | 9.42 ± 0.53 |
| Mutant | 14.10 ± 1.35* | 8.27 ± 0.92 | 11.58 ± 1.05 | 11.23 ± 1.14 |
Open field (bright light) |
Total distance (cm) | Control | 4436 ± 279 | 4053 ± 298 | 5126 ± 360 | 5173 ± 378 |
| Mutant | 4300 ± 193 | 3918 ± 202 | 4096 ± 225* | 4368 ± 243 |
Time in center (%) | Control | 5.28 ± 0.63 | 5.30 ± 0.85 | 6.73 ± 1.21 | 5.60 ± 0.71 |
| Mutant | 7.73 ± 0.70* | 4.37 ± 0.37 | 7.54 ± 0.70 | 6.02 ± 0.87 |
Light/dark transition |
Latency to enter light compartment (s) | Control | 42.4 ± 9.2 | 80.9 ± 21.9 | 57.3 ± 8.6 | 57.9 ± 10.1 |
| Mutant | 34.1 ± 4.8 | 92.3 ± 25.1 | 102.6 ± 28.1 | 136.9 ± 23.8** |
Distance traveled (cm) |
Light compartment | Control | 1083.9 ± 99.7 | 765.3 ± 68.0 | 828.6 ± 50.0 | 805.1 ± 79.9 |
| Mutant | 965.1 ± 82.9a | 687.4 ± 85.0 | 688.6 ± 74.0 | 545.7 ± 48.6 |
Dark compartment | Control | 1973.2 ± 94.3 | 1810.3 ± 115.4 | 1816.2 ± 97.9 | 1920.3 ± 152.3 |
| Mutant | 1736.5 ± 72.9a | 1695.6 ± 68.2 | 1758.2 ± 83.2 | 1897.3 ± 119.0 |
Elevated plus maze |
Time in open arms (%) | Control | 17.50 ± 1.96 | 8.95 ± 1.24 | 15.81 ± 2.54 | 13.81 ± 1.92 |
| Mutant | 20.40 ± 2.08 | 7.24 ± 1.96 | 12.28 ± 1.70 | 16.67 ± 3.18 |
Total entries (#) | Control | 20.59 ± 1.80 | 41.50 ± 2.42 | 47.75 ± 3.49 | 49.83 ± 2.55 |
| Mutant | 21.35 ± 2.54 | 41.58 ± 3.94 | 44.00 ± 2.73 | 46.00 ± 2.58 |
Startle |
Startle value (unitc) | Control | 2.93 ± 0.41 | 2.68 ± 0.52 | 3.21 ± 0.46 | 2.85 ± 0.35 |
| Mutant | 2.40 ± 0.37 | 2.15 ± 0.39 | 1.35 ± 0.24** | 3.71 ± 0.33 |
Prepulse inhibition |
Inhibition (%) |
74 dB | Control | 48.5 ± 4.2 | 49.3 ± 5.8 | 27.4 ± 6.4 | 24.3 ± 6.1 |
| Mutant | 48.2 ± 4.5 | 48.3 ± 4.7 | 33.0 ± 7.1 | 24.9 ± 4.4 |
78 dB | Control | 52.1 ± 4.5 | 52.1 ± 7.0 | 38.8 ± 6.7 | 34.9 ± 4.6 |
| Mutant | 54.8 ± 5.0 | 55.7 ± 6.0 | 39.2 ± 8.9 | 37.2 ± 4.4 |
82 dB | Control | 60.8 ± 4.7 | 58.6 ± 6.0 | 43.3 ± 5.8 | 39.3 ± 5.4 |
| Mutant | 64.9 ± 4.2 | 60.7 ± 6.8 | 51.6 ± 5.0 | 46.0 ± 4.5 |
Rotarod |
Latency to fall (s) |
Trial 1 | Control | 70.0 ± 13.5 | 75.1 ± 7.7 | 61.8 ± 14.8 | 44.3 ± 9.8 |
| Mutant | 42.9 ± 10.1 | 42.2 ± 9.9a | 62.0 ± 11.4 | 74.0 ± 16.0 |
Trial 2 | Control | 87.0 ± 13.7 | 97.1 ± 10.4 | 86.8 ± 14.1 | 90.0 ± 13.4 |
| Mutant | 79.6 ± 12.8 | 63.6 ± 10.9a | 82.6 ± 11.7 | 109.3 ± 15.2 |
Trial 3 | Control | 136.6 ± 9.8 | 117.8 ± 7.2 | 124.1 ± 15.3 | 138.8 ± 7.3 |
| Mutant | 104.8 ± 13.9 | 105.1 ± 11.0a | 87.7 ± 15.0 | 135.9 ± 17.7 |
Trial 4 | Control | 154.3 ± 9.7 | 119.1 ± 12.2 | 138.3 ± 10.4 | 146.6 ± 8.0 |
| Mutant | 120.3 ± 14.6 | 108.3 ± 14.0a | 106.5 ± 8.7 | 150.3 ± 13.9 |
Hanging wire test |
Latency to fall (s) | Control | 272.9 ± 10.1 | 190.6 ± 23.8 | 194.0 ± 25.6 | 249.6 ± 24.7 |
| Mutant | 168.9 ± 19.0*** | 192.9 ± 23.9 | 135.0 ± 17.8 | 247.9 ± 23.0 |
Hot plate test |
Latency to paw lick (s) | Control | 6.18 ± 0.34 | 8.38 ± 0.75 | 7.00 ± 0.55 | 7.08 ± 0.43 |
| Mutant | 6.78 ± 0.38 | 7.66 ± 0.47 | 6.03 ± 0.38 | 7.43 ± 0.33 |
Body weight (g) | Control | 25.0 ± 0.4 | 27.8 ± 0.4 | 27.1 ± 0.3 | 25.6 ± 0.5 |
| Mutant | 25.2 ± 0.5 | 25.9 ± 0.4** | 24.1 ± 0.2*** | 25.5 ± 0.6 |