Figure 8.
A, Light micrographs from neo-Timm's-stained sections, demonstrating the density of mossy fiber sprouting (arrows) in the supragranular region of naive (a, b), sham-operated (c, d), and kainic acid-injected (KA; e, f) Wistar rats (n = 5, 5, and 5, respectively) and GAERS (n = 5, 5, and 9, respectively) hippocampus. Neo-Timm's and thionin staining. Scale bars, 25 μm. B, Scoring of mossy fiber sprouting in the supragranular region of naive, sham-operated, and kainic acid-injected Wistar rats (n = 5) and GAERS (n = 9). ***p < 0.001, significantly increased sulfide/silver staining in kainic acid-injected Wistar rats and GAERS compared with their controls. +++p < 0.001, less-pronounced increase in kainic acid-injected GAERS than in kainic acid-injected Wistar rats.