Article Information
- Received October 24, 2008
- Revision received November 29, 2008
- Accepted December 1, 2008
- First published December 31, 2008.
- Version of record published December 31, 2008.
Author Information
- Jina Yun 1 , 2 ,
- Joseph H. Cao 1 ,
- Mark W. Dodson 1 , 4 ,
- Ira E. Clark 1 ,
- Pankaj Kapahi 5 ,
- Ruhena B. Chowdhury 6 , and
- Ming Guo 1 , 2 , 3 , 4
- Departments of 1Neurology and 2Molecular and Medical Pharmacology and 3Brain Research Institute, The David Geffen School of Medicine, and 4Molecular Biology Institute, University of California, Los Angeles, Los Angeles, California 90095, 5Buck Institute for Age Research, Novato, California 94945, and 6Cancer Research UK, London Research Institute, London WC2A 3PX, United Kingdom
- Correspondence should be addressed to Dr. Ming Guo, Departments of Neurology and Molecular and Medical Pharmacology, University of California, Los Angeles, 695 Charles Young Drive South, Los Angeles, CA 90095. Email: mingfly{at}ucla.edu
Author contributions
Disclosures
- Received October 24, 2008.
- Revision received November 29, 2008.
- Accepted December 1, 2008.
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This work was supported by a fellowship from the National Institutes of Health (NIH) National Research Service Award predoctoral fellowship to M.W.D., as well as grants and funds from NIH (R01, K02, K08), an American Parkinson Disease Association (APDA) grant, an APDA Center pilot grant, the Glenn Family Foundation, the Alfred P. Sloan Foundation, and the McKnight Foundation of Neuroscience to M.G. We are very grateful to M. Miura for antibodies, J. Belote for fly strains, N. Tapon and A. Whitworth for communicating unpublished results, A. Yamaguchi for generating one transgenic fly strain, B. A. Hay for insightful comments on this manuscript, F. Laski for use of his microtome, L. Cruz, H. Deng, and J. Olson for technical help, and the Guo laboratory members for discussions. J.Y. and J.H.C. performed experiments, M.W.D. performed most of the transmission electron microscopy studies, I.E.C., P.K., and R.B.C. contributed reagents, and M.G. performed experiments, supervised the project, and wrote the paper with helpful comments from M.W.D. and J.Y.
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J. H. Cao's present address: Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095
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R. B. Chowdhury's present address: Wales Cancer Trial Units, Neuadd Meirionnydd University Hospital of Wales, Cardiff CF14 4YS, UK.
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I. E. Clark's present address: Department of Molecular, Cellular, and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095.
- Correspondence should be addressed to Dr. Ming Guo, Departments of Neurology and Molecular and Medical Pharmacology, University of California, Los Angeles, 695 Charles Young Drive South, Los Angeles, CA 90095. Email: mingfly{at}ucla.edu
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