Cover legend: An artistically stylized high-magnification confocal image of ciliary neurotrophic factor (CNTF)-expressing astrocytes in the subventricular zone of the adult mouse brain. The nigrostriatal pathway regulates adult CNS neurogenesis through D2 dopamine receptors, and this neurogenesis is mediated entirely by CNTF. Astrocyte GFAP staining is shown in green, and CNTF expression is shown in red. Note the almost exclusive overlap (yellow). See the article by Yang et al. in this issue (pages 2231–2241).