Creb1αΔ | CREBβ, CREM | | Viable to adulthood | No gross abnormality of development; deficient long-term memory | Hummler et al., 1994 Bourtchuladze et al., 1994 Blendy et al., 1996b |
Creb1−/− | CREM | | Perinatal death | Enlarged ventricles; reduced commissures | Rudolph et al., 1998 |
Crem−/− | CREB | | Viable to adulthood | Circadian rhythm abnormalities; lower anxiety levels | Nantel et al., 1996 Blendy et al., 1996a Maldonado et al., 1999 |
CrebNescre Crem−/− | | Developmental (E16.5 and onward) in neuronal and glial progenitors | Perinatal death | Progressive neurodegeneration in all areas of the brain | Mantamadiotis et al., 2002 Aguado et al., 2009 |
CrebCamkcre4 Crem−/− | | Postnatal in forebrain regions | Viable to adulthood | Progressive neurodegeneration in hippocampus and striatum | Mantamadiotis et al., 2002 |