Figure 3.
Social recognition memory in young DKO and AC1+ mice. A, Both DKO and wild-type (wt) mice significantly decrease investigation of the familiar female during training sessions (p < 0.001; two-way ANOVA with repeated measures across session). B, Both wt and DKO mice show significantly increased investigation of novel (nov) over familiar (fam) mice 3 h after training (**p < 0.01; two-way ANOVA with repeated measures across exposure, Bonferroni post test). C, wt, but not DKO, mice show significantly increased investigation of novel over familiar mice 24 h after training (*p < 0.01; two-way ANOVA with repeated measures across exposure, Bonferroni post test). D, Both young adult AC1+ and wt mice significantly decrease investigation of the familiar female during training sessions (p < 0.01; two-way ANOVA with subjects matched across session). E, Both wt and AC1+ mice have a preference for novel over familiar mice 24 h after training (*p < 0.05; **p < 0.01; two-way ANOVA with repeated measures across exposure, Bonferroni post test). F, Seven days after training, AC1+, but not wt, mice show significantly increased investigation of the novel over the familiar female (*p < 0.05; two-way ANOVA with subjects repeated measures across exposure, Bonferroni post test).