Figure 1.
Recombination of floxed Sim1 allele with EIIa-Cre. A, B, Sim1 heterozygous mice generated with EIIa-Cre on a high-fat diet. A, Males (EIIa Het, n = 13; control, n = 14). B, Females (EIIa Het, n = 14; control, n = 7). C, The genotypes of germ line and EIIa heterozygotes and wild types shown by PCR. The 371 bp band shows the wild-type allele, and the 160 bp band shows the recombined allele. Error bars indicate SEM. WT, Wild type.